Mapping and Characterization of Alveolar Cells During Smoking and Chronic Obstructive Disease

Last updated: March 6, 2023
Sponsor: Centre Hospitalier Intercommunal Creteil
Overall Status: Active - Recruiting

Phase

N/A

Condition

Copd (Chronic Obstructive Pulmonary Disease)

Emphysema

Chronic Bronchitis

Treatment

N/A

Clinical Study ID

NCT05227547
CoStemCells
  • Ages > 18
  • All Genders

Study Summary

To evaluate the regenerative capacities of mesenchymal cells composing the microenvironment of alveolar type 2 cells in a population of patients, undergoing thoracic surgery for suspected cancer, who are smokers with and without COPD compared to non-smokers patients

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age ≥ 18
  2. Patient undergoing lung resection surgery (lobectomy, pneumonectomy, segmentectomy)for cancer or suspected cancer
  3. Acceptance to participate in the protocol
  4. Affiliated to a social security plan

Exclusion

Exclusion Criteria:

  1. Chronic autoimmune disease
  2. Patient under guardianship or curators
  3. Neo-adjuvant chemotherapy
  4. History of thoracic radiotherapy
  5. Pregnant woman
  6. Minor patient
  7. Person not able to consent
  8. Person deprived of liberty

Study Design

Total Participants: 186
Study Start date:
October 05, 2022
Estimated Completion Date:
October 05, 2030

Study Description

Chronic obstructive pulmonary diseases (COPD) have a major public health impact, as evidenced by the 250 million patients affected by these diseases and the 50% 5-year mortality for severe stages of chronic obstructive pulmonary disease (COPD). One pathophysiological mechanism of COPD and emphysema is a depletion of alveolar progenitor cells inducing a loss of alveolar-reparation capacities after an aggression. The genesis of these alterations and the mechanisms involved remain unknown. Alveolar type 2 cells (AT2) are the alveolar epithelial progenitor cells. AT2 proliferate and differentiate into alveolar type 1 cells (AT1) which form the alveolar-capillary barrier, along with endothelial cells, through which respiratory gas exchanges take place. The proliferation and differentiation of AT2 into AT1 are under the control of mesenchymal cells and endothelial cells located in close proximity. Together these cells form the alveolar stem cell niche. The characteristics and interactions of the different cell populations have been well described during lung growth, in the normal adult lung or during pulmonary fibrosis; however, participants are poorly described during smoking exposure and chronic obstructive diseases.

Connect with a study center

  • Rousseau-Bussac

    Créteil, 94000
    France

    Active - Recruiting

  • HEGP

    Paris, 75015
    France

    Site Not Available

  • Hopital Cochin

    Paris, 75014
    France

    Site Not Available

  • Hopital Tenon

    Paris, 75020
    France

    Site Not Available

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