Study to Evaluate the Safety, Tolerability and Efficacy of CT1812 in Subjects With Mild to Moderate Dementia With Lewy Bodies

Inclusion Criteria:

• Men or women 50-85 years of age (inclusive), meeting criteria for probable Dementiawith Lewy Bodies (DLB).

• MRI, or CT scan due to contraindication of MRI if approved by medical monitor)obtained during screening consistent with the clinical diagnosis of DLB and withoutfindings of significant exclusionary abnormalities. An historical MRI (or CT scan),up to 1 year prior to screening, may be used if there is no history of interveningneurologic disease or clinical events (such as a stroke, head trauma etc.) and thesubject is without clinical symptoms or signs suggestive of such intervening events.

• MMSE 18-27 inclusive

Exclusion Criteria:

• Any neurological condition that may be contributing to cognitive impairment aboveand beyond those caused by the subject's DLB, including any co-morbidities detectedby clinical assessment or MRI (or CT scan due to contraindication of MRI, ifapproved by medical monitor)

• Screening MRI (or historical MRI or CT scan due to contraindication of MRI ifapproved by medical monitor) or historical MRI/CT scan, if applicable. of the brainindicative of significant abnormality, including, but not limited to, priorhemorrhage or infarct > 1 cm3, >3 lacunar infarcts, cerebral contusion,encephalomalacia, aneurysm, vascular malformation, subdural hematoma, hydrocephalus,space-occupying lesion (e.g. abscess or brain tumor such as meningioma). If a smallincidental meningioma is observed, the medical monitor may be contacted to discusseligibility.

• Clinical, laboratory findings or medical history consistent with:

1. Other primary degenerative dementia (fronto-temporal dementia, Huntington'sdisease, Creutzfeldt-Jakob Disease, Down syndrome, etc.).

2. Other neurodegenerative condition (amyotrophic lateral sclerosis, etc.).

3. Seizure disorder.

4. Other infectious, metabolic or systemic diseases affecting the central nervoussystem (syphilis, present hypothyroidism, present vitamin B12 or folatedeficiency, other laboratory values etc.).

• Any major psychiatric diagnosis, including schizophrenia, bipolar disorder, andcurrent major depressive disorder as per Diagnostic and Statistical Manual of MentalDisorders Fifth Edition

• Clinically significant, advanced or unstable disease that may interfere with outcomeevaluations.