Interpretation Bias as a Mechanism of Treatment Response in OCD

Last updated: May 5, 2025
Sponsor: Mclean Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Obsessive-compulsive Disorder

Panic Disorders

Kleptomania

Treatment

Psychoeducation

Cognitive bias modification for interpretation bias

Clinical Study ID

NCT05224414
2022P000190
  • Ages > 18
  • All Genders

Study Summary

This study will conduct a randomized controlled trial of Cognitive Bias Modification for Interpretation (CBM-I) as an augmentation to treatment as usual for obsessive compulsive disorder (OCD). CBM-I is a digital intervention designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. Specifically, this study will examine the feasibility, acceptability, and clinical outcomes associated with CBM-I.

Adults with obsessive compulsive disorder (OCD) will be recruited from a treatment program for this disorder and participants will be randomly assigned to either receive:

  1. up to 12 sessions of CBM-I, or or up to 12 sessions of psychoeducation as a control condition.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. OCD Institute patients
  1. adults (> 18 years old)
  1. able to complete a computer task for 20 minutes
  1. consent to main OCD Institute study protocol
  1. primary diagnosis of OCD (as measured by a score of >16 on the Y-BOCS and aclinical diagnosis of OCD by their treatment team
  1. score of >131 on the Obsessive Beliefs Questionnaire-44 at admission [which is 1 SD above the mean score of the non-clinical sample reported in the originalvalidation paper by the Obsessive Compulsive Cognitions Working Group (2005)]

Exclusion

Exclusion Criteria:

  1. Currently experiencing acute symptoms of psychosis
  1. Psychotic disorder diagnosis

Study Design

Total Participants: 106
Treatment Group(s): 2
Primary Treatment: Psychoeducation
Phase:
Study Start date:
March 30, 2022
Estimated Completion Date:
August 31, 2026

Connect with a study center

  • McLean Hospital

    Belmont, Massachusetts 02478
    United States

    Active - Recruiting

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