Effect of Oral Isotretinoin on The Level of SerumYKL40 in Acne Vulgaris Patients

Last updated: September 1, 2022
Sponsor: Alshimaa Abbas Mohamed Ebrahim
Overall Status: Active - Not Recruiting

Phase

4

Condition

Rash

Scalp Disorders

Inflammatory Comedones

Treatment

N/A

Clinical Study ID

NCT05218486
551/7/21
  • Ages 15-60
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The aim of the study is to evaluate the effect of oral isotretinoin on SerumYKL40 in acne vulgaris patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Healthy persons of both sexes with moderate and severe acne.
  2. Age above 14 years.

Exclusion

Exclusion Criteria:

  1. Pregnant and lactating women, immunocompromised patients.
  2. History of chronic liver disease, hyperlipidemia, non-inflammatory acne conditions, ,history of neurologic disorders, history of neoplastic disorders, and history ofcardiac disease.
  3. History of systemic acne treatment for at least 4 weeks prior to inclusion and notopical treatments for at least 2 weeks.
  4. Cases with known hypersensitivity reaction to isotretinoin.

Study Design

Total Participants: 60
Study Start date:
August 01, 2021
Estimated Completion Date:
September 30, 2022

Study Description

Acne vulgaris is a common chronic inflammatory disease of the skin. It is found in about 80% of young adults and adolescents. It is a disease that affects the pilosebaceous units of the skin and may result in inflammatory or non-inflammatory lesions,Oral isotretinoin (13-cis-retinoic acid) is the only drug that counteracts all the pathogenetic mechanisms that contribute to the development of acne .The standard dose of isotretinoin is 0.5 to 1 mg/kg per day for 4 months to a cumulative dose of 120-140 mg/kg is effective in the management of acne vulgaris The scope of our study is to detect serum YKL-40 level in acne patient before and after oral isotretinoin treatment

Connect with a study center

  • Aswan university

    Aswan, 81528
    Egypt

    Site Not Available

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