The Sentinel Registry

Inclusion Criteria:

• Age 19 and more

• Undergoing TAVR with the use of SENTINEL embolic protection device

• Higher risk of cerebrovascular embolic events (any of the followings)

1. Bicuspid aortic valve

2. Calcified lesion or atherosclerosis in the ascending aorta and/or aortic arch

3. Heavy calcified aortic valve (Ca. volume > 500)

4. Chronic kidney disease

5. Prior stroke

6. Stroke risk is strongly anticipated by attending physicians

• Compatible carotid and brachiocephalic artery anatomy for SENTINEL device asdetermined by Multi-Slice Computed Tomography scan or equivalent imaging modality

• Agrees to the study protocol and the schedule of clinical follow-up and providesinformed, written consent, as approved by the appropriate Institutional ReviewBoard/Ethical Committee of the respective clinical site.

Exclusion Criteria:

• Vasculature in the right extremity precluding radial or brachial access

• Excessive tortuosity in the right radial/brachial/subclavian artery preventingSentinel System access and insertion

• Inadequate circulation to the right extremity as evidenced by signs of arteryocclusion (modified Allen's test) or absence of radial/brachial pulse

• Hemodialysis shunt, graft, or arterio-venous fistula involving the upper extremityvasculature

• Symptomatic or asymptomatic severe occlusive carotid disease requiring concomitantcarotid endarterectomy/stenting

• Undergone carotid stenting or carotid endarterectomy within the previous 6 weeks

• Concurrent medical condition with a life expectancy of less than 1 year