Anti-Secretory Drug in Treatment of Acute Watery Diarrhea

Last updated: January 21, 2022
Sponsor: Assiut University
Overall Status: Completed

Phase

1

Condition

Lactose Intolerance

Stomach Discomfort

Colic

Treatment

N/A

Clinical Study ID

NCT05216822
IRB-2/2019AZA
  • Ages 6-5
  • All Genders

Study Summary

In conclusion, racecadotril is an anti-secretory drug that exerts its antidiarrheal effect by inhibiting intestinal enkephalinase. It is effective in reducing the volume and frequency of stool output. racecadotril is well tolerated and safe by providing symptomatic relief and reducing the severity of diarrhea as an adjuvant therapy during the acute attack of gastroenteritis. It is recommended that the new generations of already discovered drugs for control of secretory diarrhea should be studied to discover the ones with fewer side effects to other systems in the body.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age group for six months - 5 years.
  • No or mild to moderate dehydration.
  • Alert patient (to tolerate oral intake since the drug is only available in oral form).

Exclusion

Exclusion Criteria:

  • Patients with severe dehydration (inability to drink because of drowsiness).
  • Patients with any serious concomitant illness that needs antibiotic treatment.
  • If severe adverse events occur at any time.
  • Chronic diarrhea.

Study Design

Total Participants: 50
Study Start date:
June 01, 2018
Estimated Completion Date:
August 31, 2018

Study Description

Background: Previous studies have shown that racecadotril is a safe and effective drug in treating children with acute diarrhea. Study Aim: to evaluate the effect of racecadotril as an adjunct to oral rehydration solution in the treatment of acute watery diarrhea among children under 5 years of age. Subjects and methods: This RCT trial included 50 children with acute watery diarrhea for 5 days or less with a frequency of three or more diarrheic stools in the past 24 hours before admission to the hospital, with no/mild to moderate dehydration.

Connect with a study center

  • Assiut University

    Asyut, 71511
    Egypt

    Site Not Available

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