Periodontal Health Status in Patients with Systemic Sclerosis

Last updated: September 16, 2024
Sponsor: University of Belgrade
Overall Status: Active - Recruiting

Phase

N/A

Condition

Collagen Vascular Diseases

Scleroderma

Scar Tissue

Treatment

periodontal examination's, determination of salivary antioxidants and cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid, Non-surgical therapy of periodontitis

Activity of antioxidants in unstimulated saliva (GPX, SOD, UA)

periodontal examination's and determination of salivary antioxidants

Clinical Study ID

NCT05215431
Unique Protocol ID: UBelgrade7
  • All Genders

Study Summary

The aim of the research will be to evaluate the effects of NSPT on clinical periodontal parameters, level of antioxidants in unstimulated saliva and the levels of biomarkers (VEGF, TGF-β, IL-17) in the GCF in SSc patients in comparison with systemically healthy controls. Twenty systemic sclerosis patients with periodontitis (SS group) and twenty systemically healthy periodontitis patients (P group) will be enrolled in the present study. The results may indicate higher periodontal destruction and antioxidant perturbations in unstimulated saliva of systemic sclerosis patients with periodontitis compared to systemically healthy periodontitis patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • established diagnoses of systemic sclerosis and periodontitis (study group),

  • age ≥ 18

  • presence of minimum 12 teeth

Exclusion

Exclusion Criteria:

  • concurrent inflammatory mediated rheumatic diseases

  • pregnancy or lactation

  • active cigarette smokers

  • a history of periodontal, antibiotics or non-steroidal drug therapy in the past 6months.

Study Design

Total Participants: 60
Treatment Group(s): 5
Primary Treatment: periodontal examination's, determination of salivary antioxidants and cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid, Non-surgical therapy of periodontitis
Phase:
Study Start date:
February 05, 2019
Estimated Completion Date:
November 01, 2024

Connect with a study center

  • Department of Periodontology and Oral medicine, School of Dental Medicine, University of Belgrade

    Belgrade, 11000
    Serbia

    Active - Recruiting

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