Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD

Last updated: June 16, 2025
Sponsor: AbbVie
Overall Status: Active - Enrolling

Phase

N/A

Condition

Geographic Atrophy

Macular Degeneration

Chemotherapy

Treatment

No intervention.

Clinical Study ID

NCT05210803
RGX-314-5102
  • All Genders

Study Summary

This is a prospective, observational study designed to evaluate the long-term safety and efficacy of RGX-314. Eligible participants are those who were previously enrolled in a clinical study of nAMD in which they received suprachoroidal space (SCS) administration of RGX-314. Enrollment of each participant in the current study should occur after the participant has completed either the end of study or early discontinuation visit in the previous (parent) clinical study. Participants will be followed for up to 5 years after RGX-314 administration (inclusive of the parent study). As such, the total study duration for each participant may vary depending on when they enroll in the current study following RGX-314 administration in the parent study.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Must provide written, signed informed consent for this study.

  2. Must have been enrolled in a previous clinical study of RGX-314 in the treatment ofnAMD and must have received an SCS injection of RGX-314 in that study.

  3. Must be willing and able to comply with all study procedures.

Exclusion

Exclusion Criteria:

  1. None

Study Design

Total Participants: 115
Treatment Group(s): 1
Primary Treatment: No intervention.
Phase:
Study Start date:
December 20, 2021
Estimated Completion Date:
March 31, 2028

Connect with a study center

  • Retinal Research Institute, LLC

    Phoenix, Arizona 85014
    United States

    Site Not Available

  • California Retina Consultants

    Bakersfield, California 93309
    United States

    Site Not Available

  • Retina-Vitreous Associates Medical Group

    Beverly Hills, California 90211
    United States

    Site Not Available

  • Northern California Retina Vitreous Associates Medical Group Inc

    Mountain View, California 94040
    United States

    Site Not Available

  • Retina Consultants San Diego

    Poway, California 92064
    United States

    Site Not Available

  • California Retina Consultants

    Santa Barbara, California 93103
    United States

    Site Not Available

  • Southeast Retina Center PC

    Augusta, Georgia 30909
    United States

    Site Not Available

  • Johns Hopkins University

    Baltimore, Maryland 21205
    United States

    Site Not Available

  • Ophthalmic Consultants of Boston

    Boston, Massachusetts 02114
    United States

    Site Not Available

  • Vitreoretinal Surgery PLLC

    Edina, Minnesota 55435
    United States

    Site Not Available

  • Sierra eye Associates

    Reno, Nevada 89502
    United States

    Site Not Available

  • Vision Research Center Eye Associates of New Mexico

    Albuquerque, New Mexico 87109
    United States

    Site Not Available

  • Retinovitreous Associates, LTD

    Philadelphia, Pennsylvania 19107
    United States

    Site Not Available

  • Charles Retina Institute, P.C

    Germantown, Tennessee 38138
    United States

    Site Not Available

  • Tennessee Retina, PC

    Nashville, Tennessee 37203
    United States

    Site Not Available

  • Retina Consultants of Texas

    The Woodlands, Texas 77384
    United States

    Site Not Available

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