Phase
Condition
Bacterial Infections
Sepsis And Septicemia
Soft Tissue Infections
Treatment
Duration of therapy
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion criteria
Infection's diagnosis while in the ICU
Severe infection in any site (defined as the presence of sepsis/septic shock or bloodstream infection or pneumonia) associated with a positive culture by MRD-GNB (Acinetobacter baumannii complex, Pseudomonas aeruginosa, and Enterobacterales bacteria, only susceptible to carbapenems and/or polymyxins)
Hemodynamically stable and afebrile (axillary temperature less than 37.8ºC) for at least 48 hours on day 7 of adequate antibiotic therapy
Consent of the team providing care to the patient regarding their inclusion in the research
Exclusion criteria
Inclusion in other experimental studies involving antimicrobial therapy
Infections that have as the primary site: endocarditis/endovascular infection, necrotizing fasciitis, osteomyelitis, abdominal abscess or other abdominal infections requiring surgical intervention (except infections that have been treated surgically, with curative character within the first 3 days of appropriate antimicrobial therapy), central nervous system Infections, empyema, prosthetic infection;
Immunosuppression defined as: neutrophil cells <1000/mm³ in the current hospitalization, HIV/AIDS diagnosis with last CD4 count <200/mm³, solid organ transplantation in the last year and/or need for increased immunosuppression due to acute rejection in the last year, hematopoietic stem cell transplantation in the last year, and/or current therapy for chronic graft-versus-host disease
Positive blood cultures for the same pathogen within 48 hours prior to randomization, when collected
Uncontrolled concomitant infection with another GNB (regardless of susceptibility profile)
Previous inclusion in this study
Known pregnancy
Patient in palliative care who has already decided not to restart antimicrobials, if necessary, or hemodynamic support measures.
Study Design
Connect with a study center
Hospital Cleriston de Andrade
Feira De Santana, Bahia 44089-340
BrazilSite Not Available
Hospital Couto Maia
Salvador, Bahia
BrazilSite Not Available
Hospital da Cidade
Salvador, Bahia
BrazilSite Not Available
Hospital OTO clinica
Fortaleza, Ceará
BrazilSite Not Available
Hospital Universitário de Brasília
Brasília, Distrito Federal 70840-901
BrazilSite Not Available
Instituto Hospital de Base do Distrito Federal
Brasília, Distrito Federal 70330-150
BrazilSite Not Available
Hospital Evangélico de Vila Velha
Vila Velha, Espirito Santo 29118-060
BrazilSite Not Available
Hospital Presidente Vargas
São Luís, Maranhão 65040-450
BrazilSite Not Available
Santa Casa de Misericórdia de Belo Horizonte
Belo Horizonte, Minas Gerais 30150-221
BrazilSite Not Available
Hospital Vila da Serra (Instituto Materno Infantil de Minas Gerais S/A)
Nova Lima, Minas Gerais 34000-000
BrazilSite Not Available
Irmandade da Santa Casa de Misericórdia de Passos
Passos, Minas Gerais 37904-020
BrazilSite Not Available
Hospital Universitário da Universidade Estadual de Londrina
Londrina, Paraná 86038-350
BrazilSite Not Available
Hospital Municipal de Maringá
Maringá, Paraná 87053-270
BrazilSite Not Available
Hospital Regional Baixo Amazonas
Santarém, Pará
BrazilSite Not Available
Hospital do Tricentenário
Olinda, Pernambuco 53120-420
BrazilSite Not Available
Hospital São João Batista
Volta Redonda, Rio De Janeiro
BrazilSite Not Available
Hospital Tacchini
Bento Gonçalves, Rio Grande Do Sul 95700-068
BrazilSite Not Available
Hospital Geral Caxias do Sul
Caxias Do Sul, Rio Grande Do Sul 95070-561
BrazilSite Not Available
Hospital Ernesto Dornelles
Porto Alegre, Rio Grande Do Sul 90160-092
BrazilSite Not Available
Hospital Nossa Senhora da Conceição
Porto Alegre, Rio Grande Do Sul
BrazilSite Not Available
Hospital São Lucas da PUC
Porto Alegre, Rio Grande Do Sul
BrazilSite Not Available
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande Do Sul 90035-903
BrazilSite Not Available
Hospital Ana Nery
Santa Cruz Do Sul, Rio Grande Do Sul 96835-090
BrazilSite Not Available
Hospital Santa Cruz
Santa Cruz Do Sul, Rio Grande Do Sul 96810-072
BrazilSite Not Available
Hospital São Lucas Sergipe - Rede D´or São Luiz
Aracaju, Sergipe
BrazilSite Not Available
Hospital Dr. Léo Orsi Bernadres - HLOB
Itapetininga, São Paulo 18.030-070
BrazilSite Not Available
Hospital Naval Marcílio Dias
Rio De Janeiro,
BrazilSite Not Available
Instituto Estadual do Cérebro Paulo Niemeyer (Pró Saúde- Associação Beneficente de Assistência Social e Hospitalar)
Rio De Janeiro,
BrazilSite Not Available
Hospital A.C Camargo
São Paulo,
BrazilSite Not Available
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