Single-cell CBD Biomarkers of Inflammation Reduction in People Living With HIV

Last updated: December 7, 2023
Sponsor: University of Florida
Overall Status: Completed

Phase

4

Condition

Inflammation

Treatment

CBD oil

Clinical Study ID

NCT05209867
IRB202101624 -A
OCR41346
  • Ages 21-60
  • All Genders

Study Summary

People living with HIV (PLWH) are affected by comorbidities appearing to be strongly related to chronic inflammation, a condition characterizing PLWH.

The investigators propose to study the effects of CBD on inflammation in PLWH, and establish the molecular role of different immune cells in this process. The investigators plan to use single cell RNA-sequencing (scRNAseq) to isolate CBD-specific cellular phenotypes from five persons with HIV who will provide blood samples before and after taking CBD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Willingness to take CBD and to participate in follow up for two months
  • Older than 21 and younger than 60
  • Under antiretroviral therapy for 5+ years and suppressed viral load (CD4 count <350cells/ml)

Exclusion

Exclusion Criteria:

  • Conditions/medications that may impair the immune response, e.g., rheumatoidarthritis, cancer, diabetes, chronic infections, CAD (Cold agglutinin disease),cellulitis, autoimmune diseases such as lupus, sarcoidosis
  • All medications that may affect inflammation such as aspirin, steroids, statins; CD4count <350cells/ml), pregnancy, and current marijuana or CBD use (urine drug screen)
  • UF(University of Florida)/Shands staff and students will not be considered forenrollment

Study Design

Total Participants: 4
Treatment Group(s): 1
Primary Treatment: CBD oil
Phase: 4
Study Start date:
May 01, 2022
Estimated Completion Date:
December 12, 2022

Connect with a study center

  • University of Florida

    Gainesville, Florida 32610
    United States

    Site Not Available

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