A Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of ATG 037 Monotherapy and Combination Therapy With Pembrolizumab in Patients With Advanced Solid Tumors

Inclusion Criteria:

1. Provision of signed and dated, written informed consent prior to any study-specificprocedures, sampling, and analyses.

2. Aged at least 18 years as of the date of consent.

3. Unresectable Stage III or Stage IV melanoma patients, who have had diseaseprogression on or after at least one prior ICI containing treatment. Patients withmucosal and uveal melanoma types are to be excluded.

4. There is at least one measurable lesion according to Response Evaluation Criteria inSolid Tumors (RECIST) version 1.1.

5. Estimated life expectancy of a minimum of 12 weeks.

6. Subjects with acquired immune checkpoint inhibitors resistance (objective responseor SD>6 months).

7. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 at ICFsignature.

8. Females should be using adequate contraceptive measures until 180 days after the endof treatment, should not be breastfeeding.

9. Male subjects should be willing to use barrier contraception, ie condoms, for theduration of the study and 180 days after the final dose of study treatment.

10. Subjects should have adequate organ function.

Exclusion Criteria:

1. Primary central nervous system disease, central nervous system metastatic disease,leptomeningeal disease, metastatic cord compression or carcinomatous meningitis.

2. Prior exposure to a CD73 inhibitor/antibody or adenosine receptor inhibitor.

3. Patients considered to have rapidly progressive disease (from the starting of priorline therapy to disease progression lasting no more than 90 days).

4. Prior therapy with any chemotherapy, immunotherapy, anticancer agents orinvestigational products from a previous clinical study within 28 days of the firstdose of study treatment or within a period during which the investigational productor systemic anticancer treatment has not been cleared from the body.

5. Radiotherapy with a wide field of radiation within 28 days, or radiotherapy with alimited field of radiation for palliation within 14 days of the first dose of studytreatment. Subject must have recovered from all radiation related toxicity, notrequiring corticosteroids.

6. Prior major surgery (excluding placement of vascular access) within 28 days of thefirst dose of study treatment or minor surgical procedures ≤7 days.

7. Except for alopecia, platinum-induced peripheral neurotoxicity (≤Grade 2). Anyunresolved toxicities from prior therapy greater than Common Terminology Criteriafor Adverse Events (CTCAE 5.0) Grade 1 at the time of ICF signature.

8. Received any prior immunotherapy and was discontinued from that treatment due to aGrade 3 or higher irAE (except endocrine disorders that can be treated withreplacement therapy) or was discontinued from that treatment due to Grade 2myocarditis or recurrent Grade 2 pneumonitis.

9. Subjects receiving unstable or increasing doses of corticosteroids.

10. As judged by the investigator, any evidence of severe or uncontrolled systemicdiseases, including uncontrolled hypertension defined as a blood pressure (BP) ≥160/100 mmHg despite medical therapy, unstable or uncompensated respiratory andrenal disease, active bleeding diseases, allogeneic stem cell transplantation, orany solid organ transplant, etc.