Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor Mavoglurant

Inclusion Criteria:

• Ages 18-45 years

• Estimated full-scale IQ>70

• Individual can cooperate with all study procedures

• No history of neurological disorder (e.g., epilepsy)

• No major medical condition (e.g., cancer)

• No history of significant head trauma

• Stable medication treatment 6 weeks prior to study enrollment

• Negative urine drug and breathe alcohol test at time of MRI scan

• Negative urine pregnancy test at time of MRI scan

• No MR contra-indications (e.g., in-body metal implant, severe claustrophobia)

• No contra-indications to study drug

Exclusion Criteria:

• A diagnosis of any psychotic disorder, or current mood or anxiety disorders underDSM-V, using the SCID-V-RV psychiatric interview

• A current diagnosis of: a) Alcohol use disorder, if severe (AUD, mild or moderate OKif no craving, tolerance, and withdrawal 3 months prior to interview) b) Substanceuse disorder

• Report of psychotic disorder in a 1º relative

• Auditory or visual impairment that interferes with test-taking

• Prenatal exposure to alcohol plus currently meeting criteria for features of fetalalcohol syndrome

• Not speaking English fluently or being a non-native English speaker, or beingeducated in a primary language other than English > grade 1

• Intellectual Disability (Full Scale IQ<70)

• Traumatic brain injury with loss of consciousness > 30 minutes or concussion in last 30 days

• Presence or history of neurosurgery or any neurologic illness that may affect brainphysiology (e.g., epilepsy, Multiple Sclerosis), including focal brain lesion seenon structural MRI (all structural scans are read by a board certified radiologist)

• A current major medical condition (e.g. cancer, heart failure)

• Current pregnancy (all females will be tested with urine screens on the day of MRI)

• Women not on an effective form of birth control/contraception or abstinent duringtime of study visits to prevent exposure of the investigational drug to suspectedfetus

• Current substance use with the exception of marijuana (THC), provided last use ofTHC was 24+ hours before visit (All participants will receive a urine screen for thepresence of marijuana, cocaine, opiates and a breath screen to detect the presenceof alcohol)

• Inability to comprehend the consent form appropriately

• Inability to cooperate with study procedures

• Other specific fMRI exclusions include metal devices, clips or fragments in body (orbital xray performed if needed)