Magnetic Resonance Imaging in Cerebral Small Vessel Disease

Last updated: July 18, 2022
Sponsor: Chinese PLA General Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT05200377
ChinaPLAGH-Radiology
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) may represent as a sensitive and robust tool to detect early changes in brain subtle structures and functions. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Clinical evidence of cerebral small vessel disease or MRI evidence of lacunar infarctsand white matter hyperintensity
  • No disability (modified Rankin's scale < 2)
  • No dementia (MMSE > 24 and absence of dependence in daily activities)
  • Able and willing to consent

Exclusion

Exclusion Criteria:

  • Contraindications to MRI
  • Standard MRI of bad quality due to movement artefacts
  • Pregnant
  • Unable to tolerate MRI

Study Design

Total Participants: 300
Study Start date:
January 01, 2022
Estimated Completion Date:
December 31, 2025

Study Description

Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) is sensitive to change in white matter structure and subtle vascular function alternation which correlates with cognition impairments in cSVD. MRI manifestation may also represent as useful surrogate marker. Development of advanced MRI technologies promotes their invaluable application in brain and vascular qualitative and quantitative assessment. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.

Connect with a study center

  • Chinese PLA General Hospital

    Beijing, 100853
    China

    Active - Recruiting

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