Improving Cerebral Blood Flow and Cognitive Function in Patients With Asymptomatic Intracranial / Carotid Stenosis With Nattokinase (ICC-PACS)

Last updated: April 16, 2023
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Carotid Artery Disease

Brain Function

Treatment

N/A

Clinical Study ID

NCT05200234
ICC-PACS
  • Ages > 40
  • All Genders

Study Summary

A randomized controlled trial will be conducted. Patients with asymptomatic intracranial / carotid stenosis will be randomized into two arms (1:1): an intervention arm and a control arm. Patients in the intervention arm will be treated with standard medical treatment combined with Natto Products V, whereas Patient in the control arm will be treated with only standard medical treatment . And the impact of Natto Products V on improving cerebral blood flow and cognitive function in patients with asymptomatic intracranial / carotid stenosis will be assessed by neuropsychological scale and multimode magnetic resonance imaging.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients aged ≥ 40 years
  • ≥ 50% stenosis in unilateral intracranial / carotid artery
  • Written informed consent available

Exclusion

Exclusion Criteria:

  • Previous history of major head trauma and any intracranial surgery
  • Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhageand other space occupying lesions
  • Extrapyramidal symptoms or mental illness which may affect neuropsychologicalmeasurement
  • severe loss of vision, hearing, or communicative ability
  • plan to be treated with surgery

Study Design

Total Participants: 100
Study Start date:
January 13, 2022
Estimated Completion Date:
December 31, 2023

Connect with a study center

  • Second Affilated Hospital of Zhejiang University, School of Medicine

    HangZhou, Zhejiang 310009
    China

    Active - Recruiting

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