Efficacy Study in Phytotherapy of an Association of Plants in the Improvement of Psychological Well-being

Inclusion Criteria:

• Age ≥ 18 and ≤ 75 years old ;

• Patient with a moderate depressive episode (F32.1 by ICD10 definition) ;

• Score HAM-D ≥ 16 and ≤ 23 at inclusion, corresponding to moderate symptoms ;

• Recent depression (less than 6 months), not managed by antidepressant orpsychotherapeutic treatment ;

• Depressive disorder not requiring, in the opinion of the investigator, initiation ofantidepressant drug therapy ;

• Patient able to understand the study information, read the information leaflet, andwilling to sign the consent form ;

• French speaking patient.

Exclusion Criteria:

• Patient with a depressive disorder of another nature or any other mental illness (schizophrenia, bipolarity, alcohol or drug addiction, etc.);

• Patient at risk of suicide (noted by the investigator, or HAM-D item 3 score > 2) orhaving attempted suicide in the last 5 years;

• Depression felt for more than 6 months ;

• Patient under psychotropic treatment (current or in the month preceding inclusion) (neuroleptic, anxiolytic, hypnotic);

• Patient on beta-blocker therapy ;

• Patient on dialysis ;

• Patient using products containing piperine or St. John's wort, or having a knowneffect on mood in the last 30 days ;

• Woman who is pregnant or breastfeeding, or has plans to become pregnant in the next 8 weeks ;

• Patient with an allergy or contraindication to one of the components of the productunder study (rhodiola or saffron) ;

• Patient unable to understand information related to the study (mental or linguisticdisability) ;

• Patient participating or having participated in the previous 3 months in anotherclinical trial ;