Phase
Condition
Platelet Disorders
Post-polycythemia Vera Myelofibrosis
Myelofibrosis
Treatment
Low-dose aspirin
Direct Oral Anticoagulants
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Patients with diagnosis of PV or ET or PreMF according to WHO or BSCH criteria (bonemarrow biopsy not compulsory).
Patients with JAK2V617F mutation (threshold allele burden > 1%).
Patients considered as "high-risk" patients:
based on age (> 60-year-old)
based on thrombotic history (compatible with antithrombotic randomization) butaged ≥ 18-year-old.
- Length of time from MPN diagnostic to inclusion will not exceed 12 months.
Exclusion
Exclusion Criteria:
Contra-indication to aspirin or DOAC due to allergic situation or recent history ofmajor bleeding.
Formal indication of treatment with aspirin or DOAC (thus precluding randomization).
Inability to give informed consent.
Patients under curatorship/guardianship
Concomitant use of a strong inhibitor or inducer of CYP3A4 (like ruxolitinib).
Chronic liver disease or chronic hepatitis.
Renal insufficiency with creatinine <30 ml/mn on Cockcroft and Gault Formula
Patient considered at high-risk of bleeding: patients with current or recent majoror clinical relevant non major bleeding gastrointestinal or cerebral bleedings
Planned pregnancy within 24 months
No appropriate contraception (estrogen contraception or no contraception) in womenof childbearing age or breastfeeding woman
PS>2 or life expectancy <12 months.
Study Design
Connect with a study center
CHU d'Angers
Angers, 49933
FranceActive - Recruiting
CH d'Annecy
Annecy, 74374
FranceSite Not Available
CH d'Argenteuil
Argenteuil, 95100
FranceSite Not Available
CH d'Avignon
Avignon, 84000
FranceActive - Recruiting
CH de la Côte Basque Bayonne
Bayonne, 64100
FranceSite Not Available
CHU Bordeaux
Bordeaux, 33604
FranceActive - Recruiting
CHU Brest
Brest, 29609
FranceActive - Recruiting
CH de Béziers
Béziers, 34500
FranceSite Not Available
Hôpital privé Cesson-Sévigné
Cesson-Sévigné, 35510
FranceSite Not Available
CHU de Clermont-Ferrand
Clermont-Ferrand, 63003
FranceSite Not Available
Hôpital Henri Mondor (APHP)
Créteil, 94010
FranceActive - Recruiting
CHU Grenoble Alpes
Grenoble, 38043
FranceActive - Recruiting
CHD Vendée La Roche Sur Yon
La Roche-sur-Yon, 85925
FranceActive - Recruiting
CHU Le Havre
Le Havre, 76083
FranceSite Not Available
CH Le Mans
Le Mans, 72000
FranceSite Not Available
CH Libourne
Libourne, 33500
FranceSite Not Available
CHU de Limoges - Hôpital Dupuytren
Limoges,
FranceActive - Recruiting
Centre Léon Bérard Lyon
Lyon, 69000
FranceSite Not Available
CHU de Montpellier
Montpellier, 34295
FranceSite Not Available
CH de Morlaix
Morlaix, 29600
FranceActive - Recruiting
CHU de Nancy
Nancy, 54511
FranceActive - Recruiting
CHU de Nantes - Hôtel-Dieu
Nantes, 44093
FranceSite Not Available
Hôpital Privé du Confluent Nantes
Nantes, 44202
FranceSite Not Available
CHR d'Orléans
Orléans, 45100
FranceActive - Recruiting
Hôpital Cochin (APHP)
Paris, 75679
FranceSite Not Available
Hôpital St-Louis (APHP)
Paris, 75010
FranceActive - Recruiting
CH de Perpignan
Perpignan, 66000
FranceSite Not Available
CH de Périgueux
Périgueux, 24019
FranceActive - Recruiting
CHIC de Quimper
Quimper, 29107
FranceActive - Recruiting
CHU de Rennes
Rennes, 35033
FranceSite Not Available
CH de Rochefort
Rochefort, 17300
FranceSite Not Available
CH de Roubaix
Roubaix, 59100
FranceActive - Recruiting
Centre Henri Becquerel de Rouen
Rouen, 76038
FranceActive - Recruiting
Institut Curie - Hôpital René Huguenin
Saint-Cloud, 92210
FranceSite Not Available
CHU La Réunion - Site Nord Félix GUYON
Saint-Denis, 97405
FranceSite Not Available
CHU La Réunion - Site Sud
Saint-Pierre, 97410
FranceSite Not Available
Institut de Cancérologie Lucien Neuwirth St-Priest-en-Jarez
Saint-Priest-en-Jarez, 42271
FranceActive - Recruiting
Clinique Sainte Anne Strasbourg
Strasbourg, 92210
FranceSite Not Available
CHU de Tours
Tours, 37044
FranceActive - Recruiting
CH Bretagne Atlantique Vannes
Vannes, 56017
FranceActive - Recruiting
CH de Versailles
Versailles, 78150
FranceSite Not Available
CH Paul-Brousse (APHP)
Villejuif, 94800
FranceSite Not Available
Médipôle Hôpital Mutualiste Villeurbanne
Villeurbanne, 69616
FranceActive - Recruiting
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