The Effect of Dietary Intervation on Endothelial Glycocalyx in COVID-19 Patients.

Last updated: May 14, 2023
Sponsor: University of Athens
Overall Status: Active - Recruiting

Phase

N/A

Condition

Covid-19

Atherosclerosis

Treatment

Placebo

Food supplement Endocalyx

Clinical Study ID

NCT05185934
668/30-11-2021
  • Ages 18-75
  • All Genders

Study Summary

The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis. The investigators will study the effect of Endocalyx on endothelial, vascular and left ventricular myocardial function in patients with COVID-19 infection.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • caucasian patients
  • hospitalization for COVID-19 infection
  • diagnosis of COVID-19 proven by PCR

Exclusion

Exclusion Criteria:

  • Pregnancy and breastfeeding
  • Foreseen inability to attend scheduled visits
  • History of acute coronary syndrome. Coronary artery disease will be excluded by aclinical history, examination and electrocardiogram.
  • Moderate or severe valve disease
  • Primary cardiomyopathies
  • Chronic obstructive pulmonary disease
  • Asthma
  • Chronic kidney disease (estimated glomerular filtration rate [eGFR] ≤60 ml/min/1.73m2)
  • Liver failure
  • Malignancies

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Placebo
Phase:
Study Start date:
June 01, 2022
Estimated Completion Date:
January 30, 2024

Study Description

Sixty patients who have been hospitalized due to COVID-19 infection will be randomized to receive food supplement Endocalyx (4 capsules per day) (n=30) or placebo (n=30) for 4 consecutive months.

Connect with a study center

  • "Attikon" University General Hospital

    Athens, Attiki 12462
    Greece

    Active - Recruiting

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