The SurgiMend PRS Retrospective Study

Inclusion Criteria:

1. The patient has reviewed the ethics-approved consent form and has provided consentfor data collection

2. Subject is a female over the age of 18 at the time of index surgery (mastectomy)

3. Subject had mastectomy performed for cancer or as a cancer prophylaxis

4. The surgical plan included one of the following approaches:

5. Immediate unilateral or bilateral prepectoral DTI or TE/I breast reconstructionfollowing nipple-sparing, skin-sparing, or skinreducing mastectomy with the useof SurgiMend® PRS or SurgiMend® PRS Meshed

6. Immediate unilateral or bilateral submuscular DTI or TE/I breast reconstructionfollowing nipple-sparing, skin-sparing, or skin-reducing mastectomy with theuse of SurgiMend® PRS or SurgiMend® PRS Meshed

7. If subject received bilateral breast reconstruction, the subject must have receivedthe same surgical technique for both breasts including the implantation ofSurgiMend® PRS or SurgiMend® PRS Meshed

8. If subject received unilateral breast reconstruction, there was no surgicalintervention on the contralateral breast within 12 months post-operatively

9. Subject underwent mastectomy (index surgery) at a minimum of 24 months prior tostudy initiation at site

Exclusion Criteria:

1. The surgical plan included muscle flaps to supplement the breast mound

2. The reconstruction plan included hybrid implant coverage with another type of mesh (e.g., use of another mesh or ADM in addition to SurgiMend®)

3. Subject had received prior breast augmentation, mastopexy, or breast reductionsurgeries (does not include breast biopsy)

4. Subject was a user of any nicotine products (cigarettes, chewing tobacco, vapor,etc.) (within 6 weeks before index surgery)

5. Subject had uncontrolled Type I or Type II diabetes (HbA1C >9)

6. Subject had previously undergone radiation therapy to the chest wall prior to indexsurgery

7. Subject had been diagnosed with advanced stage disease (stage 3 or 4, orinflammatory cancer)