Safety and Efficacy Study of First-line Treatment With QL1706 Plus Chemotherapy With or Without Bevacizumab in Women With Recurrent, or Metastatic Cervical Cancer

Inclusion Criteria:

1. Age ≥ 18 years at the time of study entry.
2. Patient has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
3. Life expectancy of at least 12 weeks.
4. At least one measurable lesion (according to RECIST v1.1)
5. Cervical squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinomadiagnosed by histopathology and confirmed by imaging as recurrent or stage ⅣB cervicalcancer.
6. No brain metastasis, or no meningeal metastasis.
7. Patients must have normal function as defined:
8. Any unresolved AEs ≤ CTCAE Grade 1 (except alopecia).
9. Negative pregnancy test for females of child-bearing potentials.
10. Patients with reproductive function agreed to take effective contraceptive measuresduring the treatment and in 6 months after the end of administration.
11. Patients must be able to understand and volunteer to sign the informed consent.

Exclusion Criteria:

1. Has received prior chemoradiotherapy within 3 months before enrollment,or has receivedprior radiotherapy within 2 weaks before enrollment.
2. Is currently participating in or has participated in a study of an investigationalagent within 4 weeks before enrollment.
3. Has any active autoimmune diseases or a history of autoimmune diseases (such as thefollowing, but not limited to: interstitial pneumonia, uveitis, enteritis, hepatitis,pituitary inflammation, vasculitis, nephritis, thyroid hyperfunction; patients withvitiligo; complete remission of asthma in childhood, can be included without anyintervention after adulthood; asthma patients who require bronchodilators for medicalintervention cannot be included).
4. Is using immunosuppressive agents or systemic hormonal therapy to achieveimmunosuppressive purposes (agents amount > 10 mg / day of prednisone or othertherapeutic hormones), and continue to use within 2 weeks before enrollment.
5. Known history of hypersensitivity to macromolecular protein preparation or anycomponents of the QL1604 formulation, or any components of the study drugs.
6. Has uncontrolled clinically significant cardiac and cerebral vascular diseases within 6 months before enrollment, including but not limited to the following: myocardialinfarction, severe or unstable angina, coronary artery/peripheral artery bypassgrafting, congestive heart failure, cerebrovascular accident (including transientischemic attack).
7. Symptomatic congestive heart failure (New York Heart Association Grade II-IV), orNCI-CTCAE v5.0 ≥ 2 arrhythmia, atrial fibrillation of any grade, or clinicallysignificant supraventricular arrhythmia or ventricular arrhythmia requirement fortreatment or intervention.
8. Has active infection or an unexplained fever > 38.5°C during screening visits(subjects with tumor fever may be enrolled at the discretion of the investigator).
9. Hepatitis b surface antigen (HBsAg) positive and/or hepatitis b core antibody (HBcAb)positive and HBVDNA>103copies/ml, hepatitis c virus antibody positive .
10. Known history of human immunodeficiency virus (HIV) infection, or other acquired orcongenital immunodeficiency diseases,or has a history of organ transplantation (exceptcorneal transplantation).
11. Has been vaccinated with live anti-tumor vaccine, or have received anti-tumorimmunotherapy, or may receive other systemic anti-tumor treatments during the studyperiod.
12. Has a clear history of neurological or mental disorders, including epilepsy ordementia.
13. Patients with other malignancies witnin 5 years( except cured basal cell carcinoma ofskin cancer, papillary thyroid carcinoma).