Comparative Study Between Fresh and Frozen Embryo Transfer in PCOS Patients Undergoing IVF Treatment

Last updated: April 11, 2022
Sponsor: Cairo University
Overall Status: Active - Recruiting

Phase

N/A

Condition

In Vitro Fertilization

Treatment

N/A

Clinical Study ID

NCT05167838
Cairo University obgyn
  • Ages 20-40
  • Female
  • Accepts Healthy Volunteers

Study Summary

The objective of our study is to compare in vitro fertilization (IVF) outcomes between fresh embryo transfer (ET) and frozen-thawed ET in women with polycystic ovary syndrome (PCOS).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Women diagnosed with PCOS according to modified Rotterdam criteria which includesmenstrual abnormalities combined with either hyperandrogenism (hirsutism diagnosed bymodified Ferriman-Gallwey score or elevated total testosterone level) or polycysticovaries.
  • Women ages ≥20 and <40years old.
  • BMI less than 35.
  • Women who have a history of infertility.
  • All patients will receive adjuvant drugs for ovulation induction (metformin frompreceding cycle, cabergoline 1 tab daily for 8 days and 500 cc colloid solution on dayof ovum pick up).

Exclusion

Exclusion Criteria:

  • History of unilateral oophorectomy.
  • Uterine abnormalities such as a malformed uterus (unicornuate, septate uterus),adenomyosis, submucous myoma or intrauterine adhesion.
  • Severe male factor for infertility such as azoospermia.
  • History of repeated ICSI trials failure.
  • Women who are unable to comply with the study procedures.

Study Design

Total Participants: 110
Study Start date:
January 01, 2022
Estimated Completion Date:
July 01, 2022

Study Description

Eligible women will be randomized to two groups in a ratio of 1:1 . Both the patients and the clinicians will be aware of the allocated arm. The patients (110) will be equally randomized into two groups:

Group A will undergo a day 3 fresh embryo transfer after ovarian stimulation, luteal phase support will be started just after follicular aspiration. Group B will have all of their embryo cryopreserved after ovarian stimulation with no luteal phase support after the aspiration and then undergo a frozen-thawed day 3 embryo transfer.

Controlled ovarian stimulation will be done using the gonadotropin releasing hormone (GnRH) antagonist protocol then human chorionic gonadotropin( HCG) 5000 IU trigger for final oocyte maturation.

Connect with a study center

  • Marwa Eid

    Cairo,
    Egypt

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.