Chronotype, Chrononutrition and Glucose Tolerance Among Prediabetic Individuals

Last updated: May 6, 2024
Sponsor: Universiti Tunku Abdul Rahman
Overall Status: Completed

Phase

N/A

Condition

Diabetes Prevention

Diabetes Mellitus, Type 2

Diabetes And Hypertension

Treatment

Lifestyle Intervention

Clinical Study ID

NCT05163964
TAR UC/EC/2021/02-3
  • Ages 18-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Chronotype and chrononutrition, both are emerging research fields in nutritional epidemiology. However, its association with glycemic control in the global population is less clear. A better understanding of how activity/ eating time can influence glucose levels in prediabetic individuals may improve strategies for blood glucose control. The present paper aims to determine the associations of chronotype and chrononutrition with glucose tolerance among prediabetic individuals in Malaysia.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Newly diagnosed prediabetic individuals who have been first seen by clinicaldieticians registered under the Ministry of Health Malaysia.
  2. Malaysian ≥ 18 years old.
  3. Those who plan to continue prediabetes care at the selected community clinic inMelaka.
  4. Those who can read, write and understand the Malay Language.

Exclusion

Exclusion Criteria:

  1. Night shift workers at least 3 times per week.
  2. Known sleep disorder.
  3. Pregnant Women.
  4. Those on oral glucose-lowering medications, diabetes supplements, anticonvulsantmedications or oral steroids currently or in the last month.
  5. Those with prior explored to any information regarding time-of-eating/time-of-activityrestriction.
  6. Those with chronic kidney disease. They are excluded as current research lack ofevidence to support the accuracy of using 24-hour continuous glucose monitoring system (CGMS) (Freestyle Libre Pro, Abbott, Germany).

Study Design

Total Participants: 120
Treatment Group(s): 1
Primary Treatment: Lifestyle Intervention
Phase:
Study Start date:
January 01, 2022
Estimated Completion Date:
December 31, 2023

Study Description

This is a prospective longitudinal study named Chrono-DMTM, that targets to recruit 166 newly diagnosed prediabetic individuals from the community clinics in Malacca, Malaysia. Respondents will be followed-up for 6 months: (1) baseline (1st oral glucose tolerance test (OGTT)); (2) second visit (at 3rd month); and (3) third visit (2nd OGTT at 6th month). Data collection includes sociodemographic and anthropometry measurements (weight, height, body fat, visceral fat, waist and hip circumference). Dietary intake and meal timing are collected using the 3-day dietary record while data on sleep pattern, light exposure, chronotype and chrononutrition will be collected using validated questionnaires. Physical activity will be captured using a validated IPAQ questionnaire and pedometer during periods of wearing Continuous glucose monitoring (CGM) sensor. CGM, fasting plasma glucose (FBG), OGTT and HbA1c are performed to assess glycemic outcomes.

Connect with a study center

  • Community Clinic Ayer Keroh

    Melaka Tengah, Melaka 75450
    Malaysia

    Site Not Available

  • Community Clinic Ayer Molek

    Melaka Tengah, Melaka 75450
    Malaysia

    Site Not Available

  • Community Clinic Bukit Rambai

    Melaka Tengah, Melaka 75450
    Malaysia

    Site Not Available

  • Community Clinic Jalan Gereja

    Melaka Tengah, Melaka 75450
    Malaysia

    Site Not Available

  • Community Clinic Klebang Besar

    Melaka Tengah, Melaka 75450
    Malaysia

    Site Not Available

  • Community Clinic Seri Tanjung

    Melaka Tengah, Melaka 75450
    Malaysia

    Site Not Available

  • Community Clinic Sungai Udang

    Melaka Tengah, Melaka 75350
    Malaysia

    Site Not Available

  • Community Clinic Tengkera

    Melaka Tengah, Melaka 75450
    Malaysia

    Site Not Available

  • Community Clinic Ujong Pasir

    Melaka Tengah, Melaka 75450
    Malaysia

    Site Not Available

  • Community Clinic Batu Berendam

    Melaka, 77000
    Malaysia

    Site Not Available

  • Community Clinic Peringgit

    Melaka, 75450
    Malaysia

    Site Not Available

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