The FuSion Program: A Prospective and Multicenter Cohort Study of Pan-Cancer Screening in Chinese Population

Last updated: April 15, 2024
Sponsor: Singlera Genomics Inc.
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cancer

Treatment

N/A

Clinical Study ID

NCT05159544
FuSion
  • Ages 40-75
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The integrative study by Fudan and Singlera for cancer early detection(The FuSion Program ) will evaluate sensitivity,specificity and positive/negative predictive value of the screening model jointly developed by FuDan University and Singlera in a 2-year follow-up corhort including 10,000 persons in routine annual physicals from dozens of hospitals. The multi-omics model for pan-cancer screening will be developed in a 3-year follow-up corhort including 50,000 natural persons in community containing genetic information of tumor families, assessment of epidemiological risk factors, tumor markers, proteomics, genomics and DNA methylation. After optimizing, the ability of this model will be validated in the Taizhou corhort in reality.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Take physical examinations in our research centers and have no cancer history;
  2. "Population Health tracking Survey - simplified version of the questionnaire" must befilled according to the research program and an annual physical examination can bereceived as follow-up ;
  3. Timely feed back the information related to tumor diagnosis in other hospitals to theinvestigator during the program;
  4. Have no birth plan for the last 3 years;
  5. Fully understand the study and voluntarily sign the informed consent.

Exclusion

Exclusion Criteria:

  1. Have been diagnosed with esophageal cancer, gastric cancer, colorectal cancer, livercancer, lung cancer, pancreatic cancer, breast cancer (including non-primary, such asrecurrence, metastasis or other complications) and other malignant tumors;
  2. Received blood transfusion, transplantation and other major operations within 3months;
  3. Participated in other interventional clinical researchs within 3 months;
  4. Pregnant or lactating women;
  5. Patients with autoimmune diseases, genetic diseases, mental diseases/disabilities andother diseases considered unsuitable for the study by the investigator;
  6. Due to poor compliance, the researcher judged that the study could not be completed.

Study Design

Total Participants: 60000
Study Start date:
July 06, 2021
Estimated Completion Date:
December 07, 2024

Connect with a study center

  • The First Affiliated Hospital of USTC (Anhui Provincial Hospital)

    Hefei, Anhui
    China

    Active - Recruiting

  • Beijing Hospital

    Beijing, Beijing
    China

    Active - Recruiting

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing, Chongqing
    China

    Active - Recruiting

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong
    China

    Active - Recruiting

  • Union Hospital affiliated to Tongji Hospital, Huazhong University of Science and Technology

    Wuhan, Hubei
    China

    Active - Recruiting

  • Third Xiangya Hospital of Central South University

    Changsha, Hunan
    China

    Active - Recruiting

  • Xiangya Hospital of Central South University

    Changsha, Hunan
    China

    Active - Recruiting

  • Jiangsu Province Hospital

    Nanjing, Jiangsu
    China

    Active - Recruiting

  • Fudan University Taizhou Institute of Health Sciences, Taizhou, China

    Taihou, Jiangsu 225300
    China

    Active - Recruiting

  • Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine

    Shanghai, Shanghai
    China

    Active - Recruiting

  • Sichuan Provincial People's Hospital

    Chengdu, Sichuan
    China

    Active - Recruiting

  • West China Hospital of Sichuan University

    Chengdu, Sichuan
    China

    Active - Recruiting

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