A Study of Pegcetacoplan for Patients With Transplant-associated Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation

Inclusion Criteria:

1. Male and female patients aged ≥ 18 years at the time of informed consent form (ICF)signature.

2. Received allogeneic HSCT.

3. Diagnosis of TA-TMA established, as per laboratory markers indicating TMA.

4. Have a diagnosis of TA-TMA that persists despite initial management of anytriggering condition.

5. Have random urine protein/creatinine ratio (rUPCR) ≥ 1 mg/mg.

6. Women of childbearing potential, defined as any women who have experienced menarcheand who are NOT permanently sterile or postmenopausal, must have a negative serumpregnancy test at screening and agree to use protocol-defined methods ofcontraception for the duration of the study and 8 weeks after their lastinvestigational medicinal product (IMP) dose. Note: Postmenopausal is defined as having had 12 consecutive months with no menseswithout an alternative medical cause.

7. Men must agree to the following for the duration of the study and 8 weeks aftertheir last dose of IMP:

8. Avoid fathering a child.

9. Use protocol-defined methods of contraception.

10. Refrain from donating sperm.

11. Patient and/or legally authorized representative must be capable of giving signedinformed consent, which includes compliance with the requirements and restrictionslisted in the ICF.

Exclusion Criteria:

1. Positive direct Coombs test.

2. Known familial or acquired ADAMTS13 deficiency.

3. Known Shiga toxin-related hemolytic uremic syndrome.

4. Known bone marrow or graft failure.

5. Diagnosis of disseminated intravascular coagulation.

6. Diagnosis of veno-occlusive disease (VOD).

7. Active GI bleeding (hematemesis or hematochezia) at baseline.

8. Body weight < 30 kg and > 100 kg.

9. Uncontrolled systemic bacterial or fungal infection, presence or suspicion ofsepsis.

10. Previously or currently treated with a complement inhibitor (approved orinvestigational).

11. Pregnancy or breastfeeding.

12. Positive human immunodeficiency virus antibody at screening or documented inpre-HSCT medical record.

13. Hepatitis C virus detectable by polymerase chain reaction at screening or documentedin pre-HSCT medical record.

14. Chronic inactive hepatitis B virus with viral loads > 1000 IU/mL (> 5000 copies/mL)at screening or documented in pre-HSCT medical record. Eligible patients who arechronic active carriers (≤ 1000 IU/mL) must receive prophylactic antiviral treatment (e.g., entecavir, tenofovir, lamivudine) according to local country guidelines.

15. Known or suspected hereditary fructose intolerance.

16. Hypersensitivity to pegcetacoplan or any of its excipients.

17. Inability to cooperate with study procedures or any condition that, in the opinionof the investigator, could increase the patient's risk by participating in the studyor confound the outcome of the study.