Accuracy of Dexcom G6® and FreeStyle Libre® Sensors in Standardized Hypoxemia Conditions

Inclusion Criteria: all population

• No history of respiratory diseases (childhood asthma, respiratory allergies, exercise-induced asthma or dyspnea)

• Willing to participate and able to sign an informed consent form (ICF)

• Being affiliated with the French Social Security

Inclusion Criteria:Patients with diabetes

• type 1 diabetes mellitus or type 2 diabetes mellitus (ADA definition)

• Age : 18 to 75 years

• stable diabetes treatment for more than 3 months

• no diabetic retinopathy

• no diabetic neuropathy

• no cardiovascular diseases

• no contra-indication for coronary computed tomography angiography or myocardial perfusion scintigraphy.

Inclusion Criteria: Healthy volunteers

• Age : 18 ; 40 years

• No diabetes

• No persistant drug use > 3 months except contraception

• Body mass index : [18,5 - 29,9] kg/m2

Non-inclusion criteria : all population

• Active smokers

• Pregnant or breastfeeding women, women of childbearing age without effective contraception

• Known allergies to the patch.

• Skin lesions at the sensor site that may interfere with sensor placement or accuracy

• Major cardiovascular complications within the past 3 months

• Decompensated congestive heart failure

• Chronic respiratory failure

• Chronic renal failure

• Resting ambient air O2 saturation ≤95%.

• Treatment with systemic corticosteroids

• Severe hypertension (≥180 mmHg systolic pressure or ≥ 100 mmHg diastolic pressure)

• Any concomitant disease or condition that the investigator believes may compromise patient safety or affect the conduct of the study

• Anemia (Hb<12g/dl)

• History of severe mountain sickness

• Concurrent participation in another clinical research study,

• Persons benefiting from enhanced protection

Non-inclusion criteria: Patients with diabetes

• Absolute contraindications to physical activity (HAS definitin) :

• Pulmonary arterial hypertension (> 60 mm Hg)

• Presence of intra-cardiac thrombus

• Acute pericardial effusion

• Severe obstructive cardiomyopathy

• Symptomatic aortic stenosis

• Recent thrombophlebitis with or without pulmonary embolism