De-convoluting Interactions Between Genes, the Cancer Environment, and the Immune System to Develop Therapies That Work for You

Last updated: January 24, 2025
Sponsor: Weill Medical College of Cornell University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Breast Cancer

Cancer

Treatment

Live Biobank

Clinical Study ID

NCT05134779
21-06023682
  • Ages 18-90
  • Female

Study Summary

This is a live biobank study for breast cancer (BC) patients where samples will be collected at inflection points in the course of the disease.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • All patients will historically proven BC are eligible to be on the study

Exclusion

Exclusion Criteria:

  • Carriers of other cancers other than breast.

Study Design

Total Participants: 400
Treatment Group(s): 1
Primary Treatment: Live Biobank
Phase:
Study Start date:
January 12, 2022
Estimated Completion Date:
December 31, 2028

Study Description

To test this hypothesis the investigators will focus on studying BC patients using an innovative approach, the DIGNITY Study (De-convoluting interactions between genes, the cancer environment, and the immune system to develop therapies that work for you) designed to building a live tissue biobank of Patient Derived Tumor Organoids (PDOs) derived from tumor at surgery, preceded or not by neoadjuvant therapy (NAT), and at recurrence/metastasis. BC patients enrolled in this study are consented to enable investigators to generate a biobank of tumor tissue (obtained from surgically removed excess that would otherwise be disposed off ) and matched blood cells ( obtained from an already existing line or a venipuncture ordered per standard of care testing) at key timepoints in their treatment course.

Connect with a study center

  • Brooklyn Methodist Hospital - NewYork Presbyterian

    New York, New York 11215
    United States

    Active - Recruiting

  • New York Presbyterian Hospital - Queens

    New York, New York 11355
    United States

    Active - Recruiting

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