Phase
Condition
Non-small Cell Lung Cancer
Treatment
docetaxel
JDQ443
Clinical Study ID
Ages 18-100 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participant has histologically confirmed locally advanced/metastatic (stageIIIB/IIIC or IV)
Participant has a KRAS G12C mutation present in tumor tissue or plasma prior toenrollment, as determined by a Novartis designated central laboratory or by acceptedlocal tests.
Participants has received one prior platinum-based chemotherapy regimen and oneprior immune checkpoint inhibitor therapy for locally advanced or metastatic disease
Participant has at least 1 evaluable (measurable or non-measurable) lesion by RECIST 1.1 at the screening visit.
Exclusion
Exclusion Criteria:
Participants who have previously received docetaxel (except if received inneoadjuvant or adjuvant setting with no progression within 12 months after the ofend of treatment), or any other KRAS G12C inhibitor.
Participant has EGFR-sensitizing mutation and/or ALK rearrangement by locallaboratory testing. Participants with other druggable alterations will be excludedif required by local guidelines.
Participant has known active central nervous system (CNS) metastases and/orcarcinomatous meningitis
Participant has an history of interstitial lung disease or pneumonitis grade > 1.
Other inclusion/exclusion criteria may apply
Study Design
Study Description
Connect with a study center
Novartis Investigative Site
Caba, Buenos Aires C1414DRK
ArgentinaSite Not Available
Novartis Investigative Site
La Plata, Buenos Aires B1900AWT
ArgentinaSite Not Available
Novartis Investigative Site
Pilar, Buenos Aires B1629AHJ
ArgentinaSite Not Available
Novartis Investigative Site
Buenos Aires, C1431FWO
ArgentinaSite Not Available
Novartis Investigative Site
Cordoba, X5000JHQ
ArgentinaSite Not Available
Novartis Investigative Site
Auchenflower, Queensland 4066
AustraliaSite Not Available
Novartis Investigative Site
Hyde Park, Queensland 4812
AustraliaSite Not Available
Novartis Investigative Site
South Brisbane, Queensland 4101
AustraliaSite Not Available
Novartis Investigative Site
Southport, Queensland 4215
AustraliaSite Not Available
Novartis Investigative Site
Rio de Janeiro, RJ 22640-000
BrazilSite Not Available
Novartis Investigative Site
Ijuí, RS 98700-000
BrazilSite Not Available
Novartis Investigative Site
Rio Grande Do Sul, 90035-001
BrazilSite Not Available
Novartis Investigative Site
Sao Paulo, 01509-010
BrazilSite Not Available
Novartis Investigative Site
Plovdiv, 4004
BulgariaSite Not Available
Novartis Investigative Site
Russe, 7002
BulgariaSite Not Available
Novartis Investigative Site
Sofia, 1303
BulgariaSite Not Available
Novartis Investigative Site
Levis, Quebec G6V 3Z1
CanadaSite Not Available
Novartis Investigative Site
Montreal, Quebec H4A 3J1
CanadaSite Not Available
Novartis Investigative Site
Sherbrooke, Quebec J1H 5N4
CanadaSite Not Available
Novartis Investigative Site
Santiago, Region Metropolitana 7560908
ChileSite Not Available
Novartis Investigative Site
Hefei, Anhui 230001
ChinaSite Not Available
Novartis Investigative Site
Fuzhou, Fujian 350014
ChinaSite Not Available
Novartis Investigative Site
Guangzhou, Guangdong 510080
ChinaSite Not Available
Novartis Investigative Site
Shenzhen, Guangdong 518000
ChinaSite Not Available
Novartis Investigative Site
Harbin, Heilongjiang 150081
ChinaSite Not Available
Novartis Investigative Site
Wuhan, Hubei 430060
ChinaSite Not Available
Novartis Investigative Site
Changsha, Hunan 410013
ChinaSite Not Available
Novartis Investigative Site
Nanjing, Jiangsu 210008
ChinaSite Not Available
Novartis Investigative Site
Shengyang, Liaoning 110042
ChinaSite Not Available
Novartis Investigative Site
Jinan, Shandong 250117
ChinaSite Not Available
Novartis Investigative Site
Shenyang, Shengyang 110041
ChinaSite Not Available
Novartis Investigative Site
Chengdu, Sichuan 610041
ChinaSite Not Available
Novartis Investigative Site
Hangzhou, Zhejiang 310003
ChinaSite Not Available
Novartis Investigative Site
Beijing, 100730
ChinaSite Not Available
Novartis Investigative Site
Chongqing, 400042
ChinaSite Not Available
Novartis Investigative Site
Shanghai, 200025
ChinaSite Not Available
Novartis Investigative Site
Zhengzhou, 450008
ChinaSite Not Available
Novartis Investigative Site
Medellin, Antioquia 050001
ColombiaSite Not Available
Novartis Investigative Site
Valledupar, Cesar 5602310
ColombiaSite Not Available
Novartis Investigative Site
Monteria, 230004
ColombiaSite Not Available
Novartis Investigative Site
Zagreb, 10000
CroatiaSite Not Available
Novartis Investigative Site
Ostrava Vitkovice, 703 84
CzechiaSite Not Available
Novartis Investigative Site
Aalborg, DK 9000
DenmarkSite Not Available
Novartis Investigative Site
Odense C, DK 5000
DenmarkSite Not Available
Novartis Investigative Site
Tartu, 50406
EstoniaSite Not Available
Novartis Investigative Site
Turku, FI-20521
FinlandSite Not Available
Novartis Investigative Site
Vaasa, 65130
FinlandSite Not Available
Novartis Investigative Site
Athens, GR 115 27
GreeceSite Not Available
Novartis Investigative Site
Heraklion Crete, 71110
GreeceSite Not Available
Novartis Investigative Site
Thessaloniki, 54622
GreeceSite Not Available
Novartis Investigative Site
Hong Kong, 999077
Hong KongSite Not Available
Novartis Investigative Site
Kowloon,
Hong KongSite Not Available
Novartis Investigative Site
Shatin,
Hong KongSite Not Available
Novartis Investigative Site
Shatin New Territories,
Hong KongSite Not Available
Novartis Investigative Site
Shatin, New Territories,
Hong KongSite Not Available
Novartis Investigative Site
Torokbalint, Pest 2045
HungarySite Not Available
Novartis Investigative Site
Budapest, 1121
HungarySite Not Available
Novartis Investigative Site
Reykjavik, IS-101
IcelandSite Not Available
Novartis Investigative Site
Hyderabad, Andhra Pradesh 500 034
IndiaSite Not Available
Novartis Investigative Site
Visakhapatnam, Andhrapradesh 530017
IndiaSite Not Available
Novartis Investigative Site
Bangalore, Karnataka 560076
IndiaSite Not Available
Novartis Investigative Site
Nashik, Maharashtra 422 004
IndiaSite Not Available
Novartis Investigative Site
Jaipur, Rajasthan 302019
IndiaSite Not Available
Novartis Investigative Site
Kolkata, West Bengal 700094
IndiaSite Not Available
Novartis Investigative Site
Delhi, 110 085
IndiaSite Not Available
Novartis Investigative Site
Mumbai, 400 012
IndiaSite Not Available
Novartis Investigative Site
Bergamo, BG 24127
ItalySite Not Available
Novartis Investigative Site
Cremona, CR 26100
ItalySite Not Available
Novartis Investigative Site
Lucca, LU 55100
ItalySite Not Available
Novartis Investigative Site
Aviano, PN 33081
ItalySite Not Available
Novartis Investigative Site
Roma, RM 00128
ItalySite Not Available
Novartis Investigative Site
Amman, 11941
JordanSite Not Available
Novartis Investigative Site
Irbid, 22110
JordanSite Not Available
Novartis Investigative Site
Daegu, Dalseo Gu 42602
Korea, Republic ofSite Not Available
Novartis Investigative Site
Seongnam Si, Gyeonggi Do 13620
Korea, Republic ofSite Not Available
Novartis Investigative Site
Busan, 49241
Korea, Republic ofSite Not Available
Novartis Investigative Site
Jinju, 660-702
Korea, Republic ofSite Not Available
Novartis Investigative Site
Seoul, 05030
Korea, Republic ofSite Not Available
Novartis Investigative Site
Ashrafieh, 166830
LebanonSite Not Available
Novartis Investigative Site
Beirut, 1107 2020
LebanonSite Not Available
Novartis Investigative Site
Dora, 90375
LebanonSite Not Available
Novartis Investigative Site
Saida, 652
LebanonSite Not Available
Novartis Investigative Site
Kuching, Sarawak 93586
MalaysiaSite Not Available
Novartis Investigative Site
Petaling Jaya, Selangor Darul Ehsan 46150
MalaysiaSite Not Available
Novartis Investigative Site
Kuala Lumpur, 59100
MalaysiaSite Not Available
Novartis Investigative Site
Cuautitlan Izcalli, Estado De Mexico 54769
MexicoSite Not Available
Novartis Investigative Site
Guadalajara, Jalisco 44280
MexicoSite Not Available
Novartis Investigative Site
Mexico City, 06760
MexicoSite Not Available
Novartis Investigative Site
Veracruz, 91900
MexicoSite Not Available
Novartis Investigative Site
Drammen, 3004
NorwaySite Not Available
Novartis Investigative Site
Oslo, NO 0450
NorwaySite Not Available
Novartis Investigative Site
Trondheim, 7006
NorwaySite Not Available
Novartis Investigative Site
Rzeszow, 35-055
PolandSite Not Available
Novartis Investigative Site
Warszawa, 02 781
PolandSite Not Available
Novartis Investigative Site
Lisboa, 1998-018
PortugalSite Not Available
Novartis Investigative Site
Matosinhos, 4454 513
PortugalSite Not Available
Novartis Investigative Site
Porto, 4100-180
PortugalSite Not Available
Novartis Investigative Site
Alba Iulia, Alba 510077
RomaniaSite Not Available
Novartis Investigative Site
Floresti, Cluj 407280
RomaniaSite Not Available
Novartis Investigative Site
Craiova, Dolj 200347
RomaniaSite Not Available
Novartis Investigative Site
Bucharest, 022328
RomaniaSite Not Available
Novartis Investigative Site
Cluj Napoca, 400058
RomaniaSite Not Available
Novartis Investigative Site
Cluj-Napoca, 400124
RomaniaSite Not Available
Novartis Investigative Site
Constanta, 905900
RomaniaSite Not Available
Novartis Investigative Site
Iasi, 700483
RomaniaSite Not Available
Novartis Investigative Site
Suceava, 727525
RomaniaSite Not Available
Novartis Investigative Site
Timisoara, 300425
RomaniaSite Not Available
Novartis Investigative Site
Belgrade, 11000
SerbiaSite Not Available
Novartis Investigative Site
Golnik, 4204
SloveniaSite Not Available
Novartis Investigative Site
Ljubljana, 1000
SloveniaSite Not Available
Novartis Investigative Site
Oviedo, Asturias 33011
SpainSite Not Available
Novartis Investigative Site
Badalona, Catalunya 08916
SpainSite Not Available
Novartis Investigative Site
Alicante, Comunidad Valenciana 03010
SpainSite Not Available
Novartis Investigative Site
La Coruna, Galicia 15006
SpainSite Not Available
Novartis Investigative Site
Pamplona, Navarra 31008
SpainSite Not Available
Novartis Investigative Site
Cordoba, 14004
SpainSite Not Available
Novartis Investigative Site
Madrid, 28009
SpainSite Not Available
Novartis Investigative Site
Tainan, 70403
TaiwanSite Not Available
Novartis Investigative Site
Taipei, 103616
TaiwanSite Not Available
Novartis Investigative Site
Taoyuan, 33305
TaiwanSite Not Available
Novartis Investigative Site
Khon Kaen, THA 40002
ThailandSite Not Available
Novartis Investigative Site
Bangkok, 10330
ThailandSite Not Available
Novartis Investigative Site
Adana, 01140
TurkeySite Not Available
Novartis Investigative Site
Ankara, 06500
TurkeySite Not Available
Novartis Investigative Site
Antalya, 07059
TurkeySite Not Available
Novartis Investigative Site
Cankaya Ankara, 06560
TurkeySite Not Available
Novartis Investigative Site
Fatih, 34093
TurkeySite Not Available
Novartis Investigative Site
Fatih / Istanbul, 34093
TurkeySite Not Available
Novartis Investigative Site
Fatih-Istanbul, 34093
TurkeySite Not Available
Novartis Investigative Site
Istanbul, 34722
TurkeySite Not Available
Novartis Investigative Site
Konya, 42080
TurkeySite Not Available
Novartis Investigative Site
Malatya, 44280
TurkeySite Not Available
Novartis Investigative Site
Pendik Istanbul, 34899
TurkeySite Not Available
Novartis Investigative Site
Sakarya, 54290
TurkeySite Not Available
Novartis Investigative Site
Stoke on Trent, Staffordshire ST46QG
United KingdomSite Not Available
Novartis Investigative Site
Staffordshire, WS11 5XY
United KingdomSite Not Available
Mid Florida Hematology And Onc Ctr
Orange, Florida 32763
United StatesSite Not Available
Mid Florida Hematology and Onc Ctr
Orange City, Florida 32763
United StatesSite Not Available
Hope and Healing Care Research
Hinsdale, Illinois 60521
United StatesSite Not Available
Exeter Hospital
Exeter, New Hampshire 03833
United StatesSite Not Available
Clinical Research Alliance Research
Lake Success, New York 11042
United StatesSite Not Available
Valley Medical Center Research
Renton, Washington 98055
United StatesSite Not Available
Valley Medical Center Research Valley Professional Center Bld
Renton, Washington 98055
United StatesSite Not Available
Novartis Investigative Site
Hanoi, 300000
VietnamSite Not Available
Novartis Investigative Site
Ho Chi Minh, 700000
VietnamSite Not Available
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