Helicobacter Pylori First-line Treatment Containing Tetracycline in Patients Allergic to Penicillin

Last updated: November 23, 2021
Sponsor: Shandong University
Overall Status: Active - Recruiting

Phase

4

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT05129176
2021-SDU-QILU-G709
  • Ages 18-70
  • All Genders

Study Summary

The purpose of this study is to assess and compare the effectiveness of levofloxacin-tetracycline -containing and metronidazole-tetracycline-containing quadruple regimens for the primary treatment of Helicobacter pylori infection in patients allergic to penicillin.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients aged 18-70 with H. pylori infection.
  • Patients Allergic to Penicillin.

Exclusion

Exclusion Criteria:

  • Patients with previous H. pylori eradication therapy.
  • Patients treated with Histamine-receptor antagonist, proton pump inhibitor, bismuthand antibiotics in the previous 4 weeks.
  • Patients with gastrectomy, acute gastrointestinal bleeding and advanced gastriccancer.
  • Patients with known or suspected allergy to study medications.
  • Currently pregnant or lactating.
  • Inability to provide informed consent

Study Design

Total Participants: 106
Study Start date:
November 23, 2021
Estimated Completion Date:
November 30, 2022

Study Description

Helicobacter pylori(H.pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer. Strongly evidence supports that H.pylori eradication is an effective approach to reduce the incidence of those pathologies.However,Helicobacter pylori eradication is a challenge in patients allergic to penicillin. Therefore, the investigators aim to assess and compare the effectiveness of levofloxacin-tetracycline -containing and metronidazole-tetracycline-containing quadruple regimens for the primary treatment of Helicobacter pylori infection in patients allergic to penicillin.

Connect with a study center

  • Qilu hospital

    Jinan, Shandong 250000
    China

    Active - Recruiting

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