Treatment for Sacroiliac Joint Pain Using Platelet-rich Plasma (PRP) Versus Steroid/Anesthetic

Last updated: April 13, 2026
Sponsor: University of Utah
Overall Status: Completed

Phase

N/A

Condition

Muscle Pain

Rheumatoid Arthritis

Arthritis And Arthritic Pain

Treatment

Sacroiliac intra-articular injection

Clinical Study ID

NCT05121961
RSCH1923
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to determine if platelet-rich plasma is superior to steroid/anesthetic for the treatment of sacroiliac joint pain.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult (>18 y/o) males and females referred for therapeutic injection to theinvestigators spine interventional service by a physiatrist or pain anesthesiologistwith a clinical diagnosis of SIJ pain confirmed by history

  • 50% or greater reduction in pain by a diagnostic anesthetic block using no more than 1.5 cc 2% lidocaine performed under imaging guidance by a pain interventionalist (PM&R, Pain Anesthesia, or Neuroradiology Spine Intervention).

  • Baseline pain must be >/=4 by numeric rating scale (NRS), at least 6 weeks inchronicity, and must not be multi-factorial (related to radiculopathy or axial painlocalizing elsewhere) by physical examination or confounding medical history (infection, inflammatory spondyloarthropathy, or osseous metastatic disease).

Exclusion

Exclusion Criteria:

  • SIJ steroid treatment within the prior 6 months.

  • Patients with a history of infection currently on antibiotic therapy

  • Usage of systemic immunosuppressants

  • Pregnancy

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: Sacroiliac intra-articular injection
Phase:
Study Start date:
February 22, 2020
Estimated Completion Date:
June 30, 2025

Study Description

All patients with sacroiliac joint pain diagnosed by a back pain specialist will undergo physical examination maneuvers and a test lidocaine injection of the joint. Patients who meet eligibility requirements will be randomized in a single-blind randomized controlled manner with a 50% chance of receiving platelet-rich plasma versus steroid/anesthetic injection of the sacroiliac joint(s).

Connect with a study center

  • University of Utah

    Salt Lake City, Utah 84132
    United States

    Site Not Available

  • Veterans Administration Salt Lake City Health Care System

    Salt Lake City, Utah 84148
    United States

    Site Not Available

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