The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)

Inclusion Criteria:

• English-proficient men and women aged ≥18 years

• Free of oncologic disease or or stable disease by clinical examination and history

• Completed neurotoxic chemotherapy such as platinum agents, taxanes, vinca alkaloids,and bortezomib at least three months prior to enrollment

• Diagnosis of CIPN based on symptom history, loss of deep tendon reflexes, or thepresence of symmetrical stocking-glove pain, numbness, or paresthesia Grade ≥1sensory pain based on the NCI Common Terminology Criteria for Adverse Events (CTCAE)version 5.0

• Self-reported moderate to severe CIPN pain, as defined by a score of 4 or greater onthe BPI-SF average pain item over the past week

• On a stable regimen (no change in three months) if taking anti-neuropathy or otherpain medications and not taking acetyl-L-carnitine 77

• Willing to adhere to requirement that no new pain medication be taken throughout thefirst 12 weeks of the study period

• Willing to adhere to all study-related procedures, including randomization to one ofthe three arms

• Patient answers "Yes" to at least one factor in the question: "Do you think yourbalance, gait, posture, alignment, or flexibility has been affected by yourexperience of CIPN?"

Exclusion Criteria:

• Patients who have received physical therapy or practiced yoga for CIPN in the past 3months. As patients who have received physical therapy or practiced yoga in thistime period may already be experiencing its benefits, we will exclude such patients.