Effects of the Mediterranean Diet During Pregnancy on the Onset of Allergies in the Offspring

Last updated: February 11, 2026
Sponsor: Federico II University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Allergies & Asthma

Obesity

Diabetes Prevention

Treatment

Nutritional intervention based on Mediterranean Diet

Clinical Study ID

NCT05119868
283/21
  • Ages 20-35
  • Female
  • Accepts Healthy Volunteers

Study Summary

Allergy prevalence is increasing steadily with some describing as the "epidemic of the twenty-first century". Maternal diet during pregnancy has been linked to offspring allergy risk, so it represents a potential target for allergy prevention. The Mediterranean Diet (MD) is considered one of the healthiest dietary models which exerts regulatory effects on immune system, due to the synergistic and interactive combinations of nutrients. We aim to study the effects of MD in pregnancy on the onset of allergic diseases at 2 years of age in the offspring.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • healthy women (aged 20-35 years), at first trimester of pregnancy, of at risk for atopy baby

Exclusion

Exclusion Criteria:

  • concomitant presence of infections;

  • concomitant presence of malignancies;

  • concomitant presence of major gastrointestinal malformations;

  • concomitant presence of immunodeficiencies;

  • concomitant presence of autoimmune diseases;

  • concomitant presence of chronic inflammatory bowel diseases;

  • concomitant presence of functional gastrointestinal disorders;

  • concomitant presence of celiac disease;

  • history of abdominal surgery with gastrointestinal resection;

  • concomitant presence of neuropsychiatric disorders;

  • concomitant presence of central nervous system disorders;

  • vegan diet;

  • twin pregnancy;

  • concomitant presence of genetic disorders;

  • concomitant presence of metabolic disorders.

Study Design

Total Participants: 276
Treatment Group(s): 1
Primary Treatment: Nutritional intervention based on Mediterranean Diet
Phase:
Study Start date:
November 02, 2021
Estimated Completion Date:
March 10, 2026

Connect with a study center

  • Department of Traslational Medical Science

    Naples, 80131
    Italy

    Site Not Available

  • Department of Traslational Medical Science - University of Naples Federico II

    Naples, 80131
    Italy

    Site Not Available

  • Department of Traslational Medical Science

    Naples 3172394, 80131
    Italy

    Site Not Available

  • Department of Traslational Medical Science - University of Naples Federico II

    Naples 3172394, 80131
    Italy

    Active - Recruiting

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