A Trial of Centanafadine Efficacy, Safety, and Tolerability in Adult Subjects With Binge Eating Disorder

Inclusion Criteria:

• Adult participants 18 to 65 years of age (inclusive) at the time of informedconsent.

• A primary diagnosis of BED, or is diagnosed at screening, according to Diagnosticand Statistical Manual of Mental Disorders - 5th Edition (DSM-5) criteria andconfirmed by the Structured Clinical Interview for DSM-5 (SCID).

• BED with a history of at least 2 binge eating days per week for 6 months prior toscreening.

• A rating of 4 or higher on the Clinical Global Impression - Severity (CGI-S) atscreening and baseline.

• Body mass index (BMI) of 18 to 45 kg/m^2, inclusive.

Exclusion Criteria:

• Lifetime history of bulimia nervosa or anorexia nervosa.

• Participation in a formal weight loss program within 3 months of screening orplanning to start a weight loss program during the trial.

• History of bariatric surgery.

• Montgomery-Asberg Depression Rating Scale (MADRS) score ≥ 18.