Phase
Condition
N/ATreatment
Tenecteplase
Standard Care (which may include intravenous Alteplase)
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- Patients presenting with posterior circulation ischemic stroke symptoms due to partialor complete basilar artery occlusion within 24 hours from symptom onset (or clinicaldeterioration/coma) or the time the patient was last known to be well.
- Patient's age is ≥18 years
- Presence of basilar artery occlusion, proven by CT Angiography or MR Angiography.Basilar artery occlusion is defined as 'potentially retrievable' occlusion at thebasilar artery. This can be a partial or complete occlusion.
- Premorbid mRS ≤3 (independent function or requiring only minor domestic assistance andable to manage alone for at least 1 week).
- Local legal requirements for consent have been satisfied.
Exclusion
Exclusion Criteria:
- Intracerebral hemorrhage (ICH) or other diagnosis (e.g. tumour) identified by baselineimaging.
- Posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) <7 onnon-contrast CT, CT Angiography source images or DWI MRI.
- Significant cerebellar mass effect or acute hydrocephalus.
- Established frank hypodensity on non-contrast CT indicating subacute infarction.
- Bilateral extensive brainstem ischemia.
- Strong suspicion of underlying intracranial atherosclerotic disease (e.g diffusearterial calcifications, basilar stenosis) or dissection which may require immediateneuro-interventional procedure with intracranial stenting and not benefit fromintravenous thrombolysis at investigator's discretion.
- Pre-stroke mRS of ≥4 (indicating moderate to severe previous disability).
- Other standard contraindications to intravenous thrombolysis.
- Contraindication to imaging with contrast agents.
- Clinically evident pregnant women.
- Current participation in another research drug treatment protocol.
- Known terminal illness such that the patients would not be expected to survive a year.
- Planned withdrawal of care or comfort care measures.
- Any condition that, in the judgment of the investigator could impose hazards to thepatient if study therapy is initiated or affect the participation of the patient inthe study.
Study Design
Study Description
Connect with a study center
Bankstown-Lidcombe Hospital
Bankstown, New South Wales
AustraliaSite Not Available
John Hunter Hospital
Newcastle, New South Wales
AustraliaSite Not Available
Liverpool Hospital
Sydney, New South Wales
AustraliaSite Not Available
Gold Coast Hospital
Gold Coast, Queensland
AustraliaSite Not Available
Princess Alexandra Hospital
Woolloongabba, Queensland 4102
AustraliaActive - Recruiting
Royal Adelaide Hospital
Adelaide, South Australia
AustraliaActive - Recruiting
Alfred Health
Melbourne, Victoria
AustraliaActive - Recruiting
Austin Hospital
Melbourne, Victoria
AustraliaSite Not Available
Box Hill Hospital
Melbourne, Victoria
AustraliaActive - Recruiting
Monash Health
Melbourne, Victoria
AustraliaSite Not Available
Royal Melbourne Hospital
Melbourne, Victoria
AustraliaActive - Recruiting
Western Health
Melbourne, Victoria
AustraliaSite Not Available
Fiona Stanley Hospital
Murdoch, Western Australia 6150
AustraliaActive - Recruiting
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