Propofol Versus Sevoflurane for Induction of GA in Infants

Last updated: July 2, 2023
Sponsor: Cairo University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Propofol

Clinical Study ID

NCT05105022
Ms_203_2021
  • Ages 1-90
  • All Genders

Study Summary

This comparative study aims to investigate the haemodynamic safety profile for induction of general anesthesia in infants 3 months or less guided by electrical cardiometry parameters versus sevoflurane.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • infants aged 3 months or less scheduled for elective surgery

Exclusion

Exclusion Criteria:

  • significant structural congenital heart disease
  • intracranial malformation.
  • preexisting hemodynamic instability.
  • history of seizures, opioids, and/or hypnotic administration.
  • prematurity (defined as gestational age <37 weeks)

Study Design

Total Participants: 122
Treatment Group(s): 1
Primary Treatment: Propofol
Phase:
Study Start date:
October 01, 2021
Estimated Completion Date:
January 01, 2024

Study Description

This study aims to investigate the hemodynamic effects of both propofol and sevoflurane for induction of anesthesia in infants less than 3 months of age by electrical cardiometry. The investigators hypothesized that propofol will have a safe hemodynamic profile for induction of anesthesia in infants less than 3 months of age as measured by electrical cardiometry in addition to its favorable pharmacokinetic profile of rapid induction and optimal intubation conditions.It is conducted at Abu Al Reesh Children's Hospital, Faculty of Medicine, Cairo University based on an institutional protocol used as a standard of care to induce anesthesia

Connect with a study center

  • Faculty of Medicine- Cairo University

    Cairo, 11562
    Egypt

    Active - Recruiting

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