Ultrasound-guided nerve blocks are an important tool for treating pain due to orthopedic
injury in the ED. They provide long lasting, opioid-sparing pain relief that is generally
safe and well-tolerated by patients1. Elderly patients with hip fractures commonly
present to the ED, and their injury can be painful. Commonly used opioid pain regimens
can have deleterious side effects, especially in elderly patients, like somnolence,
delirium, hypotension and respiratory depression.
The fascia iliaca compartment (FIC) block has become a familiar technique to emergency
physicians as a pain control treatment for hip fractures. The pericapsular nerve group
(PENG) block has recently been proposed as a novel method to treat pain due to hip,
acetabular and pelvic fracture by targeting the terminal sensory articular nerve branches
of the femoral nerve (FN), obturator nerve (ON), and accessory obturator nerve (AON). At
this time there has been no study comparing the efficacy of the two nerve blocks, PENG
and FIC.
This aim of this study is to compare the efficacy of the PENG block (20mL of Bupivacaine
0.50%) to that of the FIC block (40mL of Bupivacaine 0.25%) for patients with hip
fractures in the ED. Our hypothesis is that PENG will demonstrate analgesia that is
non-inferior to FIC. Subjective pain scores on a scale of 0 to 10 will be assessed before
and after the block. All subjects will receive 4mg of morphine after consent and prior to
the block.
A secondary aim is to show that the PENG block is preferable to the FIC block because it
does not target motor nerves, thus preserving motor function allowing for an accurate
neurological exam and hopefully providing for earlier ambulation. Also, we aim to
determine if PENG block results in an significant reduction in amount of systemic pain
medication needed for the patient.
This is a single-centered, prospective, randomized, blinded study involving patients who
present to the ED with an isolated hip fracture. Patients who meet inclusion criteria
will be consented for the study and then randomized to receive either a FIC block or a
PENG block. Patients who are potentially to be enrolled in the study will receive
standardized systemic analgesia while awaiting x-rays. If needed, patients will be
administered morphine for breakthrough pain after the nerve blocks are placed. The
exception to this standardization will be patients with a morphine allergy.
The research associate will screen for patients and confirm with the attending physician
that the subject is eligible for enrollment and is able to give consent. The patient
consented by a member of the research team, who will assess the patient's pain score on a
scale of 0 to 10 prior to the block. The patient will then be randomized to receive
either the FIC block or the PENG block to be performed by a member of the ultrasound
faculty. The research associate will be blinded to the type of block being performed by
the ultrasound faculty member. The research associate will then reassess the patient's
pain score on the 0-10 scale at the 30 minute and 60-minute mark. They will also assess
for any adverse events after the block is performed. The research associate will note the
motor function in the quadriceps muscle 30 min and 60 min after the nerve block is
placed. Any rescue medication given after the nerve block is placed in the ED will be
recorded.