Physiologic Effect of Topical Nitroglycerin on Microcirculation Capacity in Patients With Circulatory Shock.

Last updated: March 29, 2024
Sponsor: University of Pennsylvania
Overall Status: Completed

Phase

N/A

Condition

Circulation Disorders

Low Blood Pressure (Hypotension)

Treatment

Nitroglycerin Topical Product

Clinical Study ID

NCT05102734
843615
  • Ages 18-80
  • All Genders

Study Summary

This is an open-label, single center, trial that will enroll up to 25 participants with circulatory shock after cardiac surgery. Participants will be administered a topical sublingual nitroglycerin solution and assessed for changes microcirculatory blood flow using incident dark field microscopy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients receiving elective CABG or valvular surgery requiring cardiopulmonarybypass
  • Receiving postoperative catecholamine therapy to maintain a MAP > 65mmHg, cardiacindex > 2 despite initial fluid resuscitation
  • Invasive hemodynamic monitoring

Exclusion

Exclusion Criteria:

  • Surgical hemorrhage
  • Unable to tolerate sublingual microcirculatory flow imaging
  • Known intolerance or allergy to nitroglycerin
  • Inadequate microcirculation imaging (based on Massey Score)

Study Design

Total Participants: 44
Treatment Group(s): 1
Primary Treatment: Nitroglycerin Topical Product
Phase:
Study Start date:
September 01, 2021
Estimated Completion Date:
March 01, 2022

Connect with a study center

  • Hospital of the University of the Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

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