Anorexia Nervosa and Its Effects on Brain Function, Body Metabolism and Their Interaction

Last updated: December 12, 2024
Sponsor: Turku University Hospital
Overall Status: Completed

Phase

N/A

Condition

Anorexia

Vomiting

Treatment

N/A

Clinical Study ID

NCT05101538
T113/2020
  • Ages 18-32
  • Female
  • Accepts Healthy Volunteers

Study Summary

The neuromolecular and metabolic underpinnings of Anorexia Nervosa (AN) are studied using multi-modal molecular (positron emission tomography with two different radioligands) and functional (functional magnetic resonance imaging) neuroimaging in a prospective design. Subjects with AN and normal weight adolescents will be studied with PET and MRI and followed for five years.

Eligibility Criteria

Inclusion

Inclusion Criteria for AN:

  1. Female sex

  2. Age 18-32 3 years

  3. BMI < 17.5 kg/m2

  4. Currently fulfilling modified DSM-IV diagnosis of AN with or without amenorrhea,onset age before 25 years

  5. Diagnosed less than 2 years ago

For controls:

  1. Female sex

  2. Age 18-32 3 years

  3. BMI 19 20-25 kg/m2

  4. No lifetime history of obesity (BMI ≥> 30) or eating disorders

Exclusion

Exclusion Criteria:

  1. Any chronic disease or medication that could affect glucose metabolism orneurotransmission

  2. History of psychiatric disorders (excl. AN for the corresponding study group)

  3. Smoking of tobacco, taking of snuffs, or use of narcotics

  4. Abusive use of alcohol

Study Design

Total Participants: 25
Study Start date:
November 01, 2020
Estimated Completion Date:
November 01, 2024

Study Description

A total of sixty females (30 with AN, 30 healthy controls) are recruited into this prospective study. The subjects will undergo physical examination, body tissue composition measurement, functional and structural MRI of the brain and body, and positron emission tomography (PET) with ligands [18F]-FDG, and [11C]carfentanil. Subjects' weight and physical condition will be followed up for 5 years. The study will start in August 2020 and end in the fall of 2028.

Connect with a study center

  • Turku PET Centre

    Turku, 20521
    Finland

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.