Hepatocellular Carcinoma Imaging Using PSMA PET/CT

Inclusion Criteria:

• Male or female aged 18 years or older at screening

• Has provided written informed consent for participation in the study

• Must have risk factors for HCC e.g. cirrhosis, chronic hepatitis B infection with orwithout cirrhosis

• Patients with liver lesions ≥1 cm suspicious for HCC but with indeterminate featureson CT and MRI meeting LI-RADS 3 or 4 criteria planned for biopsy, OR patients withliver lesions diagnostic of HCC based on CT or MRI meeting LI-RADS 5 criteriaplanned for surgical resection

• Patients must be willing and able to comply with the protocol and procedures for theduration of the study

• Patients must be available for follow-up

Exclusion Criteria:

• Abdominal surgery or radiotherapy to the abdomen within <4 weeks of registration.Patients must have recovered from any effects of any major surgery

• Uncontrolled intercurrent illness that is likely to impede participation and orcompliance

• Any history of prostate cancer or elevated PSA level for male patients

• Other malignancies unless curatively treated with no evidence of disease withinprevious 3-years other than adequately treated non-melanoma skin cancer or melanomain situ

• Participation in another clinical study with an investigational product or anothersystemic cancer therapy administered in the last 4 weeks

• Has known psychiatric or substance abuse disorders that would interfere withcooperation with requirements of the study

• Women who are pregnant or lactating

• Cirrhosis due to congenital hepatic fibrosis, vascular disorders (e.g. Budd-Chiarisyndrome) or cardiac cirrhosis