Hepatocellular Carcinoma Imaging Using PSMA PET/CT

Inclusion Criteria:

• Male or female aged 18 years or older at screening
• Has provided written informed consent for participation in the study
• Must have risk factors for HCC e.g. cirrhosis, chronic hepatitis B infection with orwithout cirrhosis
• Patients with liver lesions ≥1 cm suspicious for HCC but with indeterminate featureson CT and MRI meeting LI-RADS 3 or 4 criteria planned for biopsy, OR patients withliver lesions diagnostic of HCC based on CT or MRI meeting LI-RADS 5 criteria plannedfor surgical resection
• Patients must be willing and able to comply with the protocol and procedures for theduration of the study
• Patients must be available for follow-up

Exclusion Criteria:

• Abdominal surgery or radiotherapy to the abdomen within <4 weeks of registration.Patients must have recovered from any effects of any major surgery
• Uncontrolled intercurrent illness that is likely to impede participation and orcompliance
• Any history of prostate cancer or elevated PSA level for male patients
• Other malignancies unless curatively treated with no evidence of disease withinprevious 3-years other than adequately treated non-melanoma skin cancer or melanoma insitu
• Participation in another clinical study with an investigational product or anothersystemic cancer therapy administered in the last 4 weeks
• Has known psychiatric or substance abuse disorders that would interfere withcooperation with requirements of the study
• Women who are pregnant or lactating
• Cirrhosis due to congenital hepatic fibrosis, vascular disorders (e.g. Budd-Chiarisyndrome) or cardiac cirrhosis