WBSI Guided Personalized Delivery of TTFields

Inclusion Criteria:

• Adult population ≥ 22 years

• Histologically confirmed diagnosis of GBM or molecular GBM according to c-IMPACT NOWcriteria

• Have undergone maximal safe surgical resection followed by either standard fullcourse radiation of 6000 cGy in 6 weeks or a hypofractionated course of 4000 cGy in 3 weeks

• 3 Harboring any genotype profiles (MGMT promoter methylation or unmethylation and/orisocitrate dehydrogenase (IDH) mutant or IDH wild-type)

• Possessing adequate hematological, hepatic and renal functions

• Willingness to receive TTFields

Exclusion Criteria:

• Presence of infra-tentorial GBM

• Pregnancy

• Significant co-morbidities at baseline which would prevent maintenance TMZ treatment

• Active implanted medical device, a skull defect (such as missing bone with noreplacement) or bullet fragments. Examples of active electronic devices include deepbrain stimulators, spinal cord stimulators, vagus nerve stimulators,pacemakers,defibrillators and programmable shunts. , other implanted electronic devices in thebrain.

• Sensitivity to conductive hydrogels like the gel used on electrocardiogram (ECG)stickers or transcutaneous electrical nerve stimulation (TENS) electrodes.

• Presence of significant hemorrhage in and around the tumor bed that may potentiallydegrade the image quality.