The Stimulation To Induce Mothers Study

Last updated: April 11, 2025
Sponsor: Yale University
Overall Status: Active - Recruiting

Phase

4

Condition

Acute Pain

Treatment

Exogenous oxytocin intravenous infusion without nipple stimulation.

Electric breast pump

Clinical Study ID

NCT05079841
2000031338
231888-1
1R01HD111633-01
  • Ages > 18
  • Female
  • Accepts Healthy Volunteers

Study Summary

The investigators propose a parallel group randomized clinical trial of intrapartum nipple stimulation versus exogenous oxytocin infusion for nulliparous women undergoing induction of labor near term. The central hypothesis is that intrapartum nipple stimulation to induce labor increases spontaneous vaginal delivery, improves patient-centered outcomes such as childbirth satisfaction, labor agentry, and pain scores, and reduces adverse neonatal and maternal outcomes in nulliparous women. The investigators will pursue the following specific aims: 1) Assess the effectiveness of intrapartum nipple stimulation on the rate of spontaneous vaginal delivery in nulliparous women, 2) Breastfeeding as the sole source of nutrition at time of maternal hospital discharge (Primary Aims); 3) Maximal percent newborn weight loss during the birth hospitalization within 72 hours of life, 4) Determine the effect of intrapartum nipple stimulation on the rate of adverse maternal and neonatal outcomes, 5) Determine the impact of intrapartum nipple stimulation on patient-centered outcomes and 6) In a sub-cohort of women who are enrolled in the trial, investigators will measure the change in oxytocin concentration from baseline to time at which patient achieves a regular contraction pattern.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Nulliparous

  • Gestational age 36 0/7 weeks and greater at enrollment

  • Singleton gestation

  • Planned to undergo initiation of exogenous oxytocin infusion by their maternity careprovider

  • Spontaneous rupture of membranes or if membranes intact, modified Bishop score ≥5and cervix dilated <6 cm within one hour of enrollment

  • Ability to give informed consent

Exclusion

Exclusion Criteria:

  • Unable to understand English or Spanish

  • Prior use of exogenous oxytocin or attempt at nipple stimulation during the currentpregnancy

  • Presence of tachysystole (defined as more than 5 contractions in 10 minutes averagedover 30 minutes), recurrent variable or late fetal decelerations, and bradycardia inthe prior 30 minutes before enrollment

  • Non-vertex presenting fetus at time of enrollment

  • Planned for cesarean delivery or contraindication to labor by institutional policy (e.g., placenta previa, vasa previa, active genital herpes infection, previoustransmural myomectomy)

  • Multi-fetal gestation (e.g., twins, triplets, and higher-order multiples)

  • Intrauterine fetal death

  • Major fetal anomaly suspected prenatally (defined as a fetal anomaly withanticipated neonatal intensive care unit admission)

  • Suspected alloimmunization (given the increased likelihood for anticipated neonatalintensive care unit admission)

  • Known severe fetal growth restriction (estimated fetal weight <3rd percentile) orabnormal umbilical artery Doppler studies (given the increased likelihood foranticipated neonatal intensive care unit admission)

  • HIV infection (nipple stimulation is not encouraged given the recommendation forthese mothers not to breastfeed)

  • Participation in another interventional study that influences management of laborand delivery or perinatal morbidity or mortality

  • History of mastectomy or other contraindication to use of electronic breast pump

  • Known allergic reactions to components of the electronic breast pump or to syntheticoxytocin intravenous solution

  • Significantly impaired consciousness or executive function (e.g., intubated orsedated)

Study Design

Total Participants: 988
Treatment Group(s): 2
Primary Treatment: Exogenous oxytocin intravenous infusion without nipple stimulation.
Phase: 4
Study Start date:
November 15, 2021
Estimated Completion Date:
March 31, 2029

Study Description

Primary Objectives

  1. To determine whether intrapartum nipple stimulation therapy with or without synthetic oxytocin changes the likelihood of achieving a spontaneous vaginal delivery compared to receipt of synthetic oxytocin infusion without nipple stimulation to induce labor.

  2. Breastfeeding as the sole source of nutrition at time of maternal hospital discharge

Secondary Objectives (if applicable)

The secondary objectives are as follows:

  1. Determine whether intrapartum nipple stimulation therapy with or without synthetic oxytocin changes the likelihood of achieving a spontaneous vaginal delivery compared to receipt of synthetic oxytocin infusion without nipple stimulation to induce labor.

  2. Determine if women who perform intrapartum nipple stimulation to induce labor have differences in other obstetric and maternal outcomes

  3. Determine if women who perform intrapartum nipple stimulation report differences in pain scores during labor, labor agentry and satisfaction scores, postpartum depression scores, and breastfeeding success compared to women who receive only intrapartum exogenous oxytocin infusion.

  4. Determine if women who perform intrapartum nipple stimulation to induce labor have similar fetal and neonatal outcomes compared to women who receive only intrapartum exogenous oxytocin infusion.

  5. Maximal percent newborn weight loss during the birth hospitalization within 72 hours of life

  6. At Yale, to measure the change in oxytocin concentration from baseline over the course of labor induction in patients undergoing induction of labor via intrapartum nipple stimulation versus continuous exogenous oxytocin infusion.

  7. At Yale, to measure circulating plasma and urine concentrations of proteins, microRNA, and small molecules using unbiased "omics" approaches, comparing patients undergoing induction of labor via intrapartum nipple stimulation versus continuous exogenous oxytocin infusion, un-ripened/unlabored control patients, and patients in spontaneous labor.

Connect with a study center

  • Yale New Haven Hospital

    New Haven, Connecticut 06510
    United States

    Active - Recruiting

  • Northwestern Memorial Hospital

    Chicago, Illinois 60611
    United States

    Site Not Available

  • Weill Cornell Medicine

    New York, New York 10065
    United States

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.