Biomarker of Diabetic Retinopathy

Last updated: April 29, 2025
Sponsor: Indiana University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Retina

Diabetic Retinopathy

Treatment

Blood draw

Clinical Study ID

NCT05079399
11656
  • Ages > 18
  • All Genders

Study Summary

Diabetic retinopathy (DR) is a complication of diabetes in which blood vessels supplying blood to the back of the eye (retina) are dysfunctional. This can lead to an improper supply of oxygen and nutrients to the retinal tissue, or it may trigger the formation of new blood vessels in response to the oxygen/nutrient deficiency. Ultimately affecting the normal vision. There is no known marker that will provide information on the health status of retinal blood vessels. Using highly specialized cells in the blood, this study will try to discover a marker of DR.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Ability to cooperate with imaging procedures.

  • Health status: established type 2 diabetes

  • No history of panretinal photocoagulation (PRP)

  • No history of treatment with intravitreal agents for past 12 months

Exclusion

Exclusion Criteria:

  • Previous or current malignancy

  • Acute or chronic infection (HIV, hepatitis B or C, tuberculosis)

  • Cerebral vascular accident or cerebral vascular procedure

  • Current pregnancy

  • History of organ transplantation

  • Presence of a graft (to avoid any effect of the graft)

  • History of previous vitrectomy

  • Subjects with a history of age-related macular degeneration age-related maculardegeneration (AMD), glaucoma, uveitis, and branched or central vein occlusion.

Study Design

Total Participants: 192
Treatment Group(s): 1
Primary Treatment: Blood draw
Phase:
Study Start date:
January 01, 2022
Estimated Completion Date:
June 30, 2026

Connect with a study center

  • Spring Mill Clinic

    Carmel, Indiana 46920
    United States

    Site Not Available

  • Spring Mill Clinic

    Carmel,, Indiana 46920
    United States

    Active - Recruiting

  • Eskenazi Eye Clinic

    Indianapolis, Indiana 46202
    United States

    Active - Recruiting

  • Glick Eye Institute

    Indianapolis, Indiana 46202
    United States

    Active - Recruiting

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