Dysregulated Urea-synthesis at Terminal Uremia

Last updated: October 12, 2021
Sponsor: University of Aarhus
Overall Status: Active - Recruiting

Phase

N/A

Condition

Nephropathy

Hyperargininemia

Kidney Failure (Pediatric)

Treatment

N/A

Clinical Study ID

NCT05076318
Dysregulated urea-synthesis
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This project will examine the dysregulation of the urea cycle in patients with terminal uremia using a validated method named "Functional Hepatic Nitrogen Clearance"

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age > or equal to 18 years
  • Chronic hemodialysis during 3 months
  • Patients with functioning arteriovenous-fistula assigned to "Center-Hemodialysis" at "Nyresygdomme, AUH Skejby"

Exclusion

Exclusion Criteria:

  • Active infection
  • Conditions with vomiting or diarrhea
  • Diabetes
  • Active disease being treated with chemotherapy, radiationtherapy, biologic- or similartreatments. Disease under observation can be included.
  • Liver disease
  • Vessels on the upper extremities not suited for cannulation
  • Prednisolone treatment during the last 8 weeks
  • Pregnancy
  • BMI > or equal to 30 or < or equal to 18
  • Physically or mentally condition that does not allow the project to be completed
  • Language-difficulties that does not allow the project to be completed

Study Design

Total Participants: 16
Study Start date:
March 01, 2021
Estimated Completion Date:
December 01, 2024

Connect with a study center

  • University Hospital Aarhus

    Aarhus N, 8200
    Denmark

    Active - Recruiting

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