Epidemiological Study in FRONtoTemporal Dementia

Last updated: November 28, 2023
Sponsor: CENTOGENE GmbH Rostock
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Memory Loss

Dementia

Frontotemporal Dementia

Treatment

Genetic Screening

Clinical Study ID

NCT05075187
EFRONT 05-2021
  • Ages 25-85
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

An international, multicenter, epidemiological observational study aims to investigate the prevalence of genetic etiologies in patients diagnosed with FTD or clinically suspected for FTD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Informed consent, which includes reference to the genetic testing, is obtained from the participant/legal guardian

  • The participant is aged between 25 to 85 years

  • The participant is diagnosed with Frontotemporal dementia (FTD) or has signs or symptoms of FTD

Study Design

Total Participants: 4500
Treatment Group(s): 1
Primary Treatment: Genetic Screening
Phase:
Study Start date:
September 01, 2021
Estimated Completion Date:
September 30, 2024

Study Description

Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous neurodegenerative disease caused by the loss or damage of nerve cells in the brain's frontal and temporal lobes. This leads to abnormalities in behaviour, personality, and language comprehension problems. Also, people with FTD show movement disorders like tremor, rigidity, difficulty in coordination, muscle spasms and weakness. FTD's etiology is sporadic or heritable. Sixty to 70% of FTD cases are sporadic, while 30 to 40% are inherited (familial aggregation). For this study, blood samples were collected from clinically diagnosed or suspected FTD patients and were analysed for a broad range of pathogenic variants in genes associated with FTD. The scientific insights acquired from this study will help identify novel therapeutic targets and develop/ investigate potential disease-modifying drugs.

Connect with a study center

  • AZ Damiaan

    Oostende, West Flanders 8400
    Belgium

    Site Not Available

  • CHU de Liege

    Liège, 4000
    Belgium

    Site Not Available

  • Hanau Hospital

    Hanau, Hessen 63450
    Germany

    Site Not Available

  • Gertrudis Klinik

    Leun, Hessen 35638
    Germany

    Site Not Available

  • University Hospital Dresden

    Dresden, Saxony 01307
    Germany

    Site Not Available

  • University Medical Center Hamburg Eppendorf

    Hamburg, Schleswig-Holstein 20246
    Germany

    Site Not Available

  • University of Lübeck

    Lübeck, Schleswig-Holstein 23562
    Germany

    Site Not Available

  • RWTH Aachen University

    Aachen, 52074
    Germany

    Site Not Available

  • Hochtaunus-Kliniken gGmbH

    Bad Homburg, 61352
    Germany

    Site Not Available

  • AGZ of Charite Universitätsmedizin Berlin

    Berlin, 12200
    Germany

    Site Not Available

  • University Hospital Cologne

    Cologne, 50937
    Germany

    Site Not Available

  • Asklepios Klinik Nord - Ochsenzoll

    Hamburg, 22419
    Germany

    Site Not Available

  • University Hospital Rostock

    Rostock, 18057
    Germany

    Site Not Available

  • Mediterraneo Hospital

    Athens, 16675
    Greece

    Site Not Available

  • University of Ioannina

    Ioánnina, 45110
    Greece

    Site Not Available

  • Università degli studi Gabriele D'Annunzio Chieti-Pescara

    Chieti, 66100
    Italy

    Site Not Available

  • Azienda Ospedaliera Universitaria Federico II di Napoli

    Napoli, 80131
    Italy

    Site Not Available

  • Azienda Ospedaliero-Universitaria di Parma

    Parma, 43126
    Italy

    Site Not Available

  • Azienda USL-IRCCS of Reggio Emilia

    Reggio Emilia, 42121
    Italy

    Site Not Available

  • Hospital Garcia de Orta

    Almada, 2805-267
    Portugal

    Site Not Available

  • Unidade Psiquiatrica Privada de Coimbra

    Coimbra, 3000-606
    Portugal

    Site Not Available

  • Hospital da Senhora da Oliveira Guimaraes

    Guimaraes, 4835-044
    Portugal

    Site Not Available

  • Hospital Beatriz Ângelo

    Loures, 2674-514
    Portugal

    Site Not Available

  • Hospital Pedro Hispano

    Matosinhos, 4464-513
    Portugal

    Site Not Available

  • CNS - campus neurológico Torres Vedras

    Torres Vedras, 2560-280
    Portugal

    Site Not Available

  • Hospital Universitari vall D´hebron

    Barcelona, 08035
    Spain

    Site Not Available

  • Hospital Clinico San Carlos

    Madrid, 28040
    Spain

    Site Not Available

  • Hospital Universitario 12 de Octubre

    Madrid, 28041
    Spain

    Site Not Available

  • Universitary Hospital La Princesa

    Madrid, 28006
    Spain

    Site Not Available

  • Clinica Universidad de Navarra

    Pamplona, 31008
    Spain

    Site Not Available

  • Marqués de Valdecilla University Hospital

    Santander, 39011
    Spain

    Site Not Available

  • Baskent University

    Ankara, 06100
    Turkey

    Site Not Available

  • Hacettepe University

    Ankara, 06100
    Turkey

    Site Not Available

  • Bezmialem Vakif University

    Istanbul, 34093
    Turkey

    Site Not Available

  • Istanbul University

    Istanbul, 34080
    Turkey

    Site Not Available

  • Koç University Hospital

    Istanbul, 34010
    Turkey

    Site Not Available

  • Izmir Economy University Medikalpark Hospital

    İzmir, 35575
    Turkey

    Site Not Available

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