High Versus Low Blood-Pressure Target in the Post Operative Care of Liver Transplantation A Randomized, Controled, Open and Unicentric Trial.

Last updated: January 15, 2024
Sponsor: University of Sao Paulo General Hospital
Overall Status: Completed

Phase

3

Condition

Vascular Diseases

Circulation Disorders

Dizzy/fainting Spells

Treatment

Usual Care

Usual Care + High Target of Mean Arterial Pressure

Clinical Study ID

NCT05068713
LIVER-PAM
  • Ages > 18
  • All Genders

Study Summary

LIVER PAM

A randomized, controled, open and unicentric trial comparing high (MAP 85-90 mmHg) and low (65-70 mmHg) target of mean arterial pressure in the first 24 hours after liver transplantation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Older than 18 y
  • Admitted in the ICU for a post operative care after liver transplant

Exclusion

Exclusion Criteria:

  • Consent refusal
  • Liver transplant due to acute liver failure
  • Renal transplant ( Previous or concomitant)
  • Refusal from the healthcare provider responsible for the patient
  • Renal substitution therapy in the prior 15 days
  • Pregnancy
  • Re-Transplant (Liver transplant in the previous 6 month)
  • Hepatorenal syndrome current treatment (Use of terlipressin + Albumin)
  • Refractory and persistent shock during or after transplant

Study Design

Total Participants: 174
Treatment Group(s): 2
Primary Treatment: Usual Care
Phase: 3
Study Start date:
August 24, 2021
Estimated Completion Date:
January 05, 2024

Connect with a study center

  • Hospital Das Clínicas Da Faculdade de Medicina Da Universidade de São Paulo

    São Paulo, SAO Paulo 05403-000
    Brazil

    Site Not Available

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