Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

Last updated: June 20, 2025
Sponsor: Pfizer
Overall Status: Active - Not Recruiting

Phase

3

Condition

Advanced Malignancies

Ovarian Cancer

Vaginal Cancer

Treatment

Axitinib

Avelumab

Talazoparib

Clinical Study ID

NCT05059522
B9991046
2021-002457-29
2023-509466-38-00
  • Ages > 18
  • All Genders

Study Summary

This Master Protocol for Avelumab Continuation Sub-Studies is to provide continued treatment access, safety follow-up, and when applicable, overall survival follow-up for eligible participants who continue to derive a benefit from study intervention in the Pfizer-sponsored Avelumab parent studies.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Any participant who is receiving study treatment and deriving significant clinicalbenefit or is in the safety and/or survival follow-up period in a Pfizer-sponsoredAvelumab Parent Study.

  2. Participants must agree to follow the reproductive criteria.

  3. Participants must be willing and able to comply with all scheduled visits, treatmentplan, and other study procedures.

Exclusion

Exclusion Criteria:

  1. Female participants who are pregnant or breastfeeding.

  2. Any medical reason that, in the opinion of the Investigator or Sponsor, precludesthe participant from inclusion in the study.

Study Design

Total Participants: 68
Treatment Group(s): 8
Primary Treatment: Axitinib
Phase: 3
Study Start date:
September 29, 2021
Estimated Completion Date:
September 30, 2026

Study Description

B9991046 is a master protocol that will consist of sub-studies from the following parent studies:

B9991001 - NCT02603432 B9991003 - NCT02684006 B9991004 - NCT02554812 B9991005 - NCT02584634 B9991009 - NCT02580058 B9991023 - NCT03317496 B9991025 - NCT03330405 B9991027

  • NCT03472560 B9991032 - NCT03565991

Connect with a study center

  • Macquarie University

    North Ryde, New South Wales 2109
    Australia

    Site Not Available

  • Mater Hospital Sydney

    Wollstonecraft, New South Wales 2060
    Australia

    Site Not Available

  • Melanoma Institute Australia

    Wollstonecraft, New South Wales 2065
    Australia

    Site Not Available

  • The Prince Charles Hospital

    Chermside, Queensland 4032
    Australia

    Site Not Available

  • Grand Hôpital de Charleroi

    Charleroi, Hainaut 6000
    Belgium

    Site Not Available

  • Grand Hôpital de Charleroi

    Gilly, Hainaut 6060
    Belgium

    Site Not Available

  • UZ Gent

    Gent, Oost-vlaanderen 9000
    Belgium

    Site Not Available

  • Cross Cancer Institute

    Edmonton, Alberta T6G 1Z2
    Canada

    Site Not Available

  • Kingston Health Sciences Centre-Kingston General Hospital Site

    Kingston, Ontario K7L 2V7
    Canada

    Site Not Available

  • Aalborg Universitetshospital, Syd

    Aalborg, Nordjylland 9000
    Denmark

    Site Not Available

  • Institut de Cancérologie de Lorraine Alexis Vautrin

    Vandoeuvre-lès-Nancy, Lorraine 54519
    France

    Site Not Available

  • Országos Onkológiai Intézet

    Budapest, 1122
    Hungary

    Site Not Available

  • Rabin Medical Center

    Petah Tikva, Hamerkaz 4941492
    Israel

    Site Not Available

  • S.C. Farmacia Ospedaliera

    Milano, Lombardia 20133
    Italy

    Site Not Available

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, Milano 20133
    Italy

    Site Not Available

  • IRCCS Istituto Clinico Humanitas

    Rozzano, Milano 20089
    Italy

    Site Not Available

  • Istituto Clinico Humanitas

    Rozzano, Milano 20089
    Italy

    Site Not Available

  • Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I - G.M. Lancisi - G. Salesi

    Ancona, 60126
    Italy

    Site Not Available

  • AOU Policlinico Umberto I

    Roma, 00161
    Italy

    Site Not Available

  • National Cancer Center Hospital

    Chuo-ku, Tokyo 104-0045
    Japan

    Site Not Available

  • Japanese Foundation for Cancer Research

    Koto, Tokyo 135-8550
    Japan

    Site Not Available

  • Oita University Hospital

    Yufu, Ōita 879-5593
    Japan

    Site Not Available

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395
    Japan

    Site Not Available

  • Gachon University Gil Medical Center

    Namdong-gu, Incheon-gwangyeoksi [incheon] 21565
    Korea, Republic of

    Site Not Available

  • National Cancer Center

    Goyang-si, Kyǒnggi-do 10408
    Korea, Republic of

    Site Not Available

  • Seoul National University Bundang Hospital

    Seongnam, Kyǒnggi-do 13620
    Korea, Republic of

    Site Not Available

  • Asan Medical Center

    Seoul, Seoul-teukbyeolsi [seoul] 05505
    Korea, Republic of

    Site Not Available

  • Samsung Medical Center

    Seoul, Seoul-teukbyeolsi [seoul] 06351
    Korea, Republic of

    Site Not Available

  • Seoul National University Hospital

    Seoul, Seoul-teukbyeolsi [seoul] 03080
    Korea, Republic of

    Site Not Available

  • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

    Monterrey, Nuevo LEÓN 64460
    Mexico

    Site Not Available

  • Oaxaca Site Management Organization S.C.

    Oaxaca, 68000
    Mexico

    Site Not Available

  • Auckland City Hospital

    Auckland, 1023
    New Zealand

    Site Not Available

  • Centralny Szpital Kliniczny MSWiA w Warszawie

    Warszawa, 02-507
    Poland

    Site Not Available

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie

    Warszawa, 02-781
    Poland

    Site Not Available

  • Budgetary Healthcare Institution of Omsk Region "Clinical Oncology Dispensary"

    Omsk, Omskaya Oblast' 644013
    Russian Federation

    Site Not Available

  • Private Medical Institution "Euromedservice"

    Pushkin, Saint - Petersburg 196603
    Russian Federation

    Site Not Available

  • GBUZ SK Pyatigorsk Interdistrict Oncology dispensary

    Pyatigorsk, Stavropol'skiy KRAY 357502
    Russian Federation

    Site Not Available

  • Moscow Scientific Research Oncology Institute n.a. P.A. Hertzen

    Moscow, 125284
    Russian Federation

    Site Not Available

  • FBIH "Privolzhskiy Regional Medical Center" of FMBA

    Nizhniy Novgorod, 603109
    Russian Federation

    Site Not Available

  • SAHI Republican Clinical Oncology Dispensary under the Ministry of Health, Republic of Bashkortostan

    Ufa, 450054
    Russian Federation

    Site Not Available

  • Institute for Oncology and Radiology of Serbia

    Belgrade, 11000
    Serbia

    Site Not Available

  • Institut Català d'Oncologia - L'Hospitalet

    Hospitalet de Llobregat, Barcelona 08908
    Spain

    Site Not Available

  • Hospital Clínic de Barcelona

    Barcelona, Barcelona [barcelona] 08036
    Spain

    Site Not Available

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035
    Spain

    Site Not Available

  • Hospital Universitario Fundación Jiménez Díaz

    Madrid, 28040
    Spain

    Site Not Available

  • Hospital Universitario HM Sanchinarro

    Madrid, 28050
    Spain

    Site Not Available

  • Hospital Universitario Virgen de Valme

    Sevilla, 41014
    Spain

    Site Not Available

  • National Cheng Kung University Hospital

    Tainan, 704
    Taiwan

    Site Not Available

  • National Taiwan University Hospital

    Taipei, 10002
    Taiwan

    Site Not Available

  • Chang Gung Medical Foundation-Linkou Branch

    Taoyuan, 333
    Taiwan

    Site Not Available

  • Royal Marsden Hospital (Chelsea)

    London, Kensington AND Chelsea SW3 6JJ
    United Kingdom

    Site Not Available

  • The Newcastle Upon Tyne Hospitals NHS Foundation Trust

    Newcastle Upon Tyne, NE7 7DN
    United Kingdom

    Site Not Available

  • Royal Cornwall Hospitals NHS Trust

    Truro, TR1 3LJ
    United Kingdom

    Site Not Available

  • Highlands Oncology Group, PA

    Fayetteville, Arkansas 72703
    United States

    Site Not Available

  • Highlands Oncology Group, PA

    Rogers, Arkansas 72758
    United States

    Site Not Available

  • Highlands Oncology Group, PA

    Springdale, Arkansas 72762
    United States

    Site Not Available

  • Ronald Reagan UCLA Medical Center - Drug Information Center, Pharmaceutical Services

    Los Angeles, California 90095
    United States

    Site Not Available

  • UCLA Hematology/Oncology

    Los Angeles, California 90095
    United States

    Site Not Available

  • UCLA Hematology/Oncology - Administrative Office

    Los Angeles, California 90024
    United States

    Site Not Available

  • Moffitt Cancer Center

    Tampa, Florida 33612
    United States

    Site Not Available

  • MSK Basking Ridge

    Basking Ridge, New Jersey 07920
    United States

    Site Not Available

  • MSK Monmouth

    Middletown, New Jersey 07748
    United States

    Site Not Available

  • MSK Bergen

    Montvale, New Jersey 07645
    United States

    Site Not Available

  • MSK Commack

    Commack, New York 11725
    United States

    Site Not Available

  • MSK Westchester

    Harrison, New York 10604
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy

    Long Island City, New York 11101
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center

    New York, New York 10065
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).

    New York, New York 10021
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center 53rd street.

    New York, New York 10022
    United States

    Site Not Available

  • MSK Nassau

    Uniondale, New York 11553
    United States

    Site Not Available

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas 77030
    United States

    Site Not Available

  • Fred Hutchinson Cancer Center

    Seattle, Washington 98109
    United States

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.