Reappraisal of the Therapies of Refractory Autoimmune Hemolytic Anemia in Systemic Lupus Erythematosus

Last updated: October 20, 2021
Sponsor: Assiut University
Overall Status: Active - Not Recruiting

Phase

3

Condition

Systemic Lupus Erythematosus

Anemia

Bone Diseases

Treatment

N/A

Clinical Study ID

NCT05057481
17300600
  • Ages > 18
  • All Genders

Study Summary

There is a deficiency in guidelines about the treatment of autoimmune hemolytic anemia in systemic lupus erythematosus (SLE), especially in refractory cases. Mycophenolate mofetil (MMF) showed promising results in those patients but still, the data available are in form of case reports. So, investigators will investigate the efficiency of MMF against a well-established treatment Rituximab in the treatment of refractory autoimmune hemolytic anemia in SLE patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • diagnosis of erythematosus (SLE) according to The American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) guidelines.
  • secondary autoimmune hemolytic anemia (AIHA) that does not respond properly tocorticosteroid or when the patients are intolerant to treatment, or refuse standardtreatment.

Exclusion

Exclusion Criteria:

  • Pregnant or breastfeeding women.
  • any contraindication of the used drugs.
  • any known hypersensitivity of the used drugs.
  • congenital hemolytic anemia.
  • chronic renal failure.

Study Design

Total Participants: 30
Study Start date:
September 15, 2021
Estimated Completion Date:
January 15, 2023

Study Description

There is a deficiency in guidelines about the treatment of autoimmune hemolytic anemia in systemic lupus erythematosus (SLE), especially in refractory cases. Mycophenolate mofetil (MMF) showed promising results in those patients but still, the data available are in form of case reports. So, the investigators will investigate the efficiency of MMF against a well-established treatment Rituximab in the treatment of refractory autoimmune hemolytic anemia in SLE patients.

Connect with a study center

  • faculty of medicine, Assiut university

    Assiut, 17111
    Egypt

    Site Not Available

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