Wide Excision of Soft Tissue Sarcomas in Combination With Interstitial Radiation Therapy

Inclusion Criteria:

• C49.1 Malignant neoplasm of the connective and soft tissues of the upper limb,including the shoulder girdle
• C49.2 Malignant neoplasm of the connective and soft tissues of the lower limb,including the hip region
• Tumor size 7 cm or less
• For malignant tumors: Grade 2-3
• Locally advanced soft tissue sarcomas
• Absence of regional metastases
• Tumor recurrence

Exclusion Criteria:

• Children, women during pregnancy, childbirth, women during breastfeeding.
• Military personnel, with the exception of contract military personnel.
• Persons with mental disorders.
• Persons detained, taken into custody, serving a sentence in the form of restriction offreedom, arrest, imprisonment or administrative arrest.
• The age of patients is under 18 years old
• Histologically confirmed diagnosis of GIST, Kaposi's sarcoma, alveolar, clear cellsarcoma, chondrosarcoma, paraossal osteosarcoma
• Inoperable tumor
• A tumor with decay or with the threat of decay
• The presence of damage to the skin in the affected area
• The presence of a second malignant tumor
• Having an active or chronic fungal / bacterial / viral infection
• Uncontrolled chronic diseases of the liver, kidneys in the acute stage
• Superficial tumor (within the skin)
• The use of a reconstructive plastic component using a displaced musculocutaneous flap
• The use of vascular prosthetics
• The removed tumor bed is more than 7 cm
• The presence of a tumor growing into the bone
• The presence of blood vessels and nerves in the removed tumor bed
• Presence of metastases
• Surgical intervention using transplanted skin