Right Ventricular Function and Pulmonary Hypertension in HFpEF

Last updated: September 14, 2021
Sponsor: Heart Center Leipzig - University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Failure

Chest Pain

Hyponatremia

Treatment

N/A

Clinical Study ID

NCT05055180
HFpEF-PHT 1.1
  • Ages > 18
  • All Genders

Study Summary

In patients with heart failure and preserved ejection fraction (HFpEF) right ventricular (RV) systolic and diastolic dysfunction are prognostically and functionally relevant factors but have mechanistically been neglected so far. In the present study alterations of intrinsic RV (systolic and diastolic) function, as assessed by invasive pressure volume loops, are examined in relation to tissue alterations on myocardial level and to the degree of RV afterload (pulmonary hypertension). Study aim is to gain insights into mechanisms contributing to the development of RV dysfunction and potentially identify new therapeutic targets.

Eligibility Criteria

Inclusion

HFpEF Inclusion Criteria:

  • Clinical signs of heart failure
  • Preserved Left ventricular (LV) Ejection Fraction (EF >= 50%)
  • Structural Heart Diseases on echocardiogram/ N terminal-pro-brain natriuretic peptide > 125ng/l
  • Elevated LV end-diastolic pressure at rest (>15mmHg) or during exertion (>=25mmHg) No Heart Failure Inclusion Criteria:
  • No signs of heart failure
  • Preserved Left ventricular (LV) Ejection Fraction (EF >= 50%)
  • Normal LV end-diastolic pressure at rest (=<15mmHg) and during exertion (<25mmHg)

Exclusion

Exclusion Criteria:

  • Significant coronary artery stenosis at time of catheterization
  • Acute coronary syndrome or cerebral insult within 1 month of examination
  • more than moderate valvular diseases
  • pregnancy
  • contraindication to cardiac magnetic resonance imaging

Study Design

Total Participants: 45
Study Start date:
October 01, 2018
Estimated Completion Date:
December 30, 2021

Connect with a study center

  • Heart Center Leipzig at Leipzig University

    Leipzig, Saxony 04289
    Germany

    Active - Recruiting

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