Respiratory Muscles and Work of Breathing in Children

Last updated: October 28, 2024
Sponsor: Assistance Publique - Hôpitaux de Paris
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neurologic Disorders

Dystonias

Pentalogy Of Cantrell

Treatment

Esogastric pressure measurement

Clinical Study ID

NCT05051254
APHP210261
ID-RCB 2020-A03393-36
  • Ages < 17
  • All Genders

Study Summary

Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology of respiratory impairment and guide therapeutic management. The use of an invasive technique (esogastric probe) makes it possible to specifically explore the diaphragm, the accessory inspiratory muscles and the expiratory muscles in order to detect dysfunction or paralysis of these muscles, and to estimate the work of breathing in order to better guide the respiratory management.

The primary objective of the study is to evaluate the respiratory effort in children with primary or secondary impairment of the respiratory muscles during spontaneous breathing or during mechanical ventilation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients aged less than 18 years old with primary or secondary impairment ofrespiratory muscles and followed at Necker Hospital

  • Patients under spontaneous breathing or noninvasive or invasive mechanicalventilation

  • Written informed consent

Exclusion

Exclusion Criteria:

  • No social insurance

  • Significant psychomotor retardation

  • Absence of cooperation

  • Significant agitation

  • Hemodynamic instability

  • Acute condition or temporary drug treatments that may interfere with the results ofthe respiratory muscle explorations

Study Design

Total Participants: 550
Treatment Group(s): 1
Primary Treatment: Esogastric pressure measurement
Phase:
Study Start date:
January 19, 2022
Estimated Completion Date:
January 31, 2028

Study Description

Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology of respiratory impairment and guide therapeutic management. The use of an invasive technique (esogastric probe) makes it possible to specifically explore the diaphragm, the accessory inspiratory muscles and the expiratory muscles in order to detect dysfunction or paralysis of these muscles, and to estimate the work of breathing in order to better guide the respiratory management.

Respiratory muscle testing by means of esogastric measurements may allow assessing the effect of pharmacological treatment by comparing respiratory muscle strength before and after a few months with treatment. Moreover, esogastric measurements can be used to better adapt mechanical ventilation or to determine the possibility of weaning from the respiratory support.

The primary objective of the study is to evaluate the respiratory effort in children with primary or secondary impairment of the respiratory muscles during spontaneous breathing or during mechanical ventilation.

Connect with a study center

  • Hôpital Necker-Enfants Malades

    Paris, 75015
    France

    Active - Recruiting

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