Early Stage Follicular LymphOma and RadioTherapy PLUS Anti-CD20 Antibody

Inclusion Criteria:

• • Centrally reviewed CD20-positive follicular lymphoma grade 1/2 or 3a based on WHOclassification (2008)

• Untreated (radiation-, chemo- or immunotherapy) nodal follicular lymphoma (including involvement of Waldeyer´s ring)

• Age: ≥18 years

• ECOG: 0-2

• Stage: clinical stage I or II (Ann Arbor classification) based on FDG-PETStaging

• Risk profile: Largest diameter of the lymphoma ≤ 7 cm (sectional images)

• Written informed consent and willingness to cooperate during the course of thetrial

• Adequate bone marrow capacity: ANC ≥ 1.5 x 103/ml, thrombocytes ≥ 100000 x 10 3/ml, hemoglobin ≥ 10 g/dL

• Capability to understand the intention and the consequences of the clinicaltrial

• Adequate contraception for men and women of child-bearing age during therapyand 18 months thereafter

Exclusion Criteria:

• Extra nodal manifestation of follicular lymphoma

• Secondary cancer in the patient's medical history (exclusion: basalioma, spinalioma,melanoma in situ, bladder cancer T1a, non-metastasized solid tumor in constantremission, which was diagnosed >3 years ago)

• Serious disease interfering with a regular therapy according to the study protocol,e.g: congenital or acquired immune-deficiency syndromes, active infections includingviral hepatitis, uncontrolled concomitant diseases including significantcardiovascular or pulmonary disease

• Severe psychiatric disease

• Pregnancy / lactation

• Known hypersensitivity against Obinutuzumab or Rituximab drugs with similar chemicalstructure or any other additive of the pharmaceutical formula of the study drug

• Active hepatitis B infection (inactive hepatitis B infections require additionalprophylactic anti-viral medication for 1 year (e.g. Lamivudin, Entecavir, Tenofovir)

• Participation in another interventional trial or follow-up period of a competingtrial which can influence the results of this current trial

• Creatinine > 1.5 times the upper limit of normal (ULN) (unless creatinine clearancenormal), or calculated creatinine clearance < 40 mL/min

• AST or ALT > 2.5 × ULN

• Total bilirubin ≥ 1.5 × ULN

• INR > 1.5 × ULN

• PTT or aPTT > 1.5 × the ULN