Direct Selective Laser Trabeculoplasty in Ethnic Chinese Population The Zhuiguang Trial

Inclusion Criteria:

1. Age 40 years or older, any gender, of Chinese Han ethnicity, with corrected visualacuity > 6/60 in both eyes
2. Open angle glaucoma including exfoliative or pigmentary glaucoma or ocularhypertension.
3. IOP ≥ 22mmHg to ≤35mmHg (after washout of any IOP-lowering medications) forparticipants.
4. Gonioscopically visible scleral spur for 360 degrees without indentation
5. Ability to visualize the peri-limbal sclera for 360 degrees (using a lid speculum)
6. Willing and able to participate in the 12-month study, to comply with the studyprocedures and to adhere to the follow-up schedule.
7. Participant capable of giving informed consent

Exclusion Criteria:

1. Contraindications to conventional laser trabeculoplasty (e.g., corneal abnormalities,etc.)
2. Angle Closure Glaucoma
3. Congenital or developmental glaucoma
4. Secondary glaucoma except exfoliative or pigmentary glaucoma
5. Presence of any Peripheral Anterior Synechiae (PAS) in the study eye
6. Inability to conduct a reliable visual field (defined as fixation losses, falsepositives or false negatives greater than 33%)
7. Any of the following visual field findings using the Humphrey visual field analyzerthe SITA-standard 24-2 program:
8. A visual field MD of worse than -12dB
9. Greater than or equal to 75% of points depressed below the 5% level and greaterthan or equal to 50% of points depressed below the 1% level on the PD plot.
10. At least 50% of points (i.e 2 or more) within the central 5 degrees with asensitivity ≤0dB on the decibel plot
11. Points within the central 5 degrees of fixation with a sensitivity <15 dB in bothhemifields on the decibel plot
12. A visual field MD of worse than -12dB in the fellow eye
13. Cup:Disc Ratio of more than 0.8
14. More than three hypotensive medications required (combination drops are considered as 2 medications)
15. Prior incisional or laser glaucoma surgery (including previous SLT or LPI) in thestudy eye.
16. Prior corneal refractive surgery
17. Complicated cataract surgery ≤ 6 months prior to enrollment
18. Presence of visually significant cataract in the opinion of the investigator
19. Clinically significant disease in either eye as determined by the Investigator.
20. Clinically significant amblyopia in either eye
21. Dense pigmentation or haemorrhage in the peri-limbal conjunctiva or anterior sclera
22. Women who are pregnant or may become pregnant during the course of the study.
23. In the opinion of the investigator the participant might require other ocular surgerywithin the 12-month follow-up period, unless for further reduction of their IOP
24. Concurrent treatment with topical, nasal, inhaled or systemic steroids.
25. Uncontrolled systemic disease that could impact the ability of the participant toattend follow up visits as per the discretion of the investigator.
26. Participation in another clinical study, not including a GLAUrious sub-study